| pubmed-article:16005216 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C0028040 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C0026837 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C0006030 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C0242948 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C1512693 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:16005216 | lifeskim:mentions | umls-concept:C0231517 | lld:lifeskim |
| pubmed-article:16005216 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:16005216 | pubmed:dateCreated | 2005-8-2 | lld:pubmed |
| pubmed-article:16005216 | pubmed:abstractText | The alpha7 nAChR subtype is of particular interest as a potential therapeutic target since it has been implicated as a mediator of both cognitive and neuroprotective activity. The rigid nicotine analog ACME and the N-cyanoborane conjugate ACME-B are selective partial agonists of rat alpha7 receptors expressed in Xenopus oocytes, with no significant activation of either alpha3beta4 or alpha4beta2 receptors. ACME-B is both more potent and efficacious than ACME. The efficacies of ACME-B and ACME are approximately 26% and 10% of the efficacy of ACh, respectively. Similar N-conjugation of S(-)nicotine with cyanoborane decreased efficacy for alpha3beta4 and alpha4beta2 receptors, as well as for alpha7 nAChR. Structural comparison of ACME with the benzylidene anabaseines, another class of previously identified alpha7-selective agonists, suggests that they share a similar structural motif that may be applicable to other alpha7-selective agonists. | lld:pubmed |
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| pubmed-article:16005216 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16005216 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16005216 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16005216 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16005216 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16005216 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:16005216 | pubmed:author | pubmed-author:DwoskinLinda... | lld:pubmed |
| pubmed-article:16005216 | pubmed:author | pubmed-author:CrooksPeter... | lld:pubmed |
| pubmed-article:16005216 | pubmed:author | pubmed-author:PapkeRoger... | lld:pubmed |
| pubmed-article:16005216 | pubmed:author | pubmed-author:ZhengGuangron... | lld:pubmed |
| pubmed-article:16005216 | pubmed:author | pubmed-author:HorensteinNic... | lld:pubmed |
| pubmed-article:16005216 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16005216 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16005216 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:16005216 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16005216 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16005216 | pubmed:pagination | 3874-80 | lld:pubmed |
| pubmed-article:16005216 | pubmed:dateRevised | 2010-6-4 | lld:pubmed |
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| pubmed-article:16005216 | pubmed:meshHeading | pubmed-meshheading:16005216... | lld:pubmed |
| pubmed-article:16005216 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16005216 | pubmed:articleTitle | The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion. | lld:pubmed |
| pubmed-article:16005216 | pubmed:affiliation | University of Florida, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA. rlpapke@ufl.edu | lld:pubmed |
| pubmed-article:16005216 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16005216 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16005216 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:16005216 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16005216 | lld:pubmed |
