| pubmed-article:16004930 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16004930 | lifeskim:mentions | umls-concept:C0002062 | lld:lifeskim |
| pubmed-article:16004930 | lifeskim:mentions | umls-concept:C1511660 | lld:lifeskim |
| pubmed-article:16004930 | lifeskim:mentions | umls-concept:C0085241 | lld:lifeskim |
| pubmed-article:16004930 | lifeskim:mentions | umls-concept:C0025513 | lld:lifeskim |
| pubmed-article:16004930 | lifeskim:mentions | umls-concept:C1522538 | lld:lifeskim |
| pubmed-article:16004930 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:16004930 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16004930 | pubmed:dateCreated | 2005-7-11 | lld:pubmed |
| pubmed-article:16004930 | pubmed:abstractText | Monocrotaline is a representative naturally occurring genotoxic pyrrolizidine alkaloid. Metabolism of monocrotaline by liver microsomes of F344 female rats generated (+/-)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) and monocrotaline-N-oxide as major metabolites. Metabolism in the presence of triacetyleandomycin, a P450 3A enzyme inhibitor, reduced the formation of DHP by 52% and monocrotaline N-oxide formation by 59%. Dexamethasone significantly induced microsomal monocrotaline metabolizing enzyme activities in rat liver and lung. Previously, we have identified a set of DHP-derived DNA adducts from DHP-modified calf thymus DNA by (32)P-post labeling/HPLC analysis. Metabolism of monocrotaline in the presence of calf thymus DNA resulted in a similar set of DHP-DNA adducts. These DHP-DNA adducts were also found in the liver DNA of rats treated with monocrotaline. The time course of the DHP-derived DNA adduct formation and removal in the liver of rats gavaged with a single dose (10mg/kg) of monocrotaline was similar to that of rats treated with riddelliine. The levels of DHP-DNA adducts in liver DNA of rats treated with monocrotaline were much lower than that of riddelliine-treated rats. Results from this study indicate that (i) DHP is a common reactive metabolite for retronecine-type of pyrrolizidine alkaloids, (ii) the formation of DHP-derived DNA adducts in the liver DNA of rats treated with monocrotaline suggests that monocrotaline-induced tumorigenicity is through a genotoxic mechanism. | lld:pubmed |
| pubmed-article:16004930 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16004930 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004930 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16004930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004930 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16004930 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16004930 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:16004930 | pubmed:author | pubmed-author:YanJianJ | lld:pubmed |
| pubmed-article:16004930 | pubmed:author | pubmed-author:FuPeter PPP | lld:pubmed |
| pubmed-article:16004930 | pubmed:author | pubmed-author:WangYu-PingYP | lld:pubmed |
| pubmed-article:16004930 | pubmed:author | pubmed-author:BegerRichard... | lld:pubmed |
| pubmed-article:16004930 | pubmed:author | pubmed-author:ChouMing WMW | lld:pubmed |
| pubmed-article:16004930 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16004930 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:16004930 | pubmed:volume | 226 | lld:pubmed |
| pubmed-article:16004930 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16004930 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16004930 | pubmed:pagination | 27-35 | lld:pubmed |
| pubmed-article:16004930 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16004930 | pubmed:meshHeading | pubmed-meshheading:16004930... | lld:pubmed |
| pubmed-article:16004930 | pubmed:meshHeading | pubmed-meshheading:16004930... | lld:pubmed |
| pubmed-article:16004930 | pubmed:meshHeading | pubmed-meshheading:16004930... | lld:pubmed |
| pubmed-article:16004930 | pubmed:meshHeading | pubmed-meshheading:16004930... | lld:pubmed |
| pubmed-article:16004930 | pubmed:meshHeading | pubmed-meshheading:16004930... | lld:pubmed |
| pubmed-article:16004930 | pubmed:meshHeading | pubmed-meshheading:16004930... | lld:pubmed |
| pubmed-article:16004930 | pubmed:meshHeading | pubmed-meshheading:16004930... | lld:pubmed |
| pubmed-article:16004930 | pubmed:meshHeading | pubmed-meshheading:16004930... | lld:pubmed |
| pubmed-article:16004930 | pubmed:meshHeading | pubmed-meshheading:16004930... | lld:pubmed |
| pubmed-article:16004930 | pubmed:meshHeading | pubmed-meshheading:16004930... | lld:pubmed |
| pubmed-article:16004930 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16004930 | pubmed:articleTitle | Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo. | lld:pubmed |
| pubmed-article:16004930 | pubmed:affiliation | Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA. | lld:pubmed |
| pubmed-article:16004930 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16004930 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:16004930 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16004930 | lld:pubmed |
