| pubmed-article:16002669 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16002669 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:16002669 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16002669 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:16002669 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:16002669 | lifeskim:mentions | umls-concept:C1337615 | lld:lifeskim |
| pubmed-article:16002669 | lifeskim:mentions | umls-concept:C0443264 | lld:lifeskim |
| pubmed-article:16002669 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16002669 | pubmed:dateCreated | 2005-7-8 | lld:pubmed |
| pubmed-article:16002669 | pubmed:abstractText | Technical difficulties in tracking endogenous CD4 T lymphocytes have limited the characterization of tumor-specific CD4 T cell responses. Using fluorescent MHC class II/peptide multimers, we defined the fate of endogenous Leishmania receptor for activated C kinase (LACK)-specific CD4 T cells in mice bearing LACK-expressing TS/A tumors. LACK-specific CD44(high)CD62L(low) CD4 T cells accumulated in the draining lymph nodes and had characteristics of effector cells, secreting IL-2 and IFN-gamma upon Ag restimulation. Increased frequencies of CD44(high)CD62L(low) LACK-experienced cells were also detected in the spleen, lung, liver, and tumor itself, but not in nondraining lymph nodes, where the cells maintained a naive phenotype. The absence of systemic redistribution of LACK-specific memory T cells correlated with the presence of tumor. Indeed, LACK-specific CD4 T cells with central memory features (IL-2(+)IFN-gamma(-)CD44(high)CD62L(high) cells) accumulated in all peripheral lymph nodes of mice immunized with LACK-pulsed dendritic cells and after tumor resection. Together, our data demonstrate that although tumor-specific CD4 effector T cells producing IFN-gamma are continuously generated in the presence of tumor, central memory CD4 T cells accumulate only after tumor resection. Thus, the continuous stimulation of tumor-specific CD4 T cells in tumor-bearing mice appears to hinder the systemic accumulation of central memory CD4 T lymphocytes. | lld:pubmed |
| pubmed-article:16002669 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16002669 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16002669 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16002669 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16002669 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16002669 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16002669 | pubmed:author | pubmed-author:BenigniFabioF | lld:pubmed |
| pubmed-article:16002669 | pubmed:author | pubmed-author:GlaichenhausN... | lld:pubmed |
| pubmed-article:16002669 | pubmed:author | pubmed-author:MalherbeLaure... | lld:pubmed |
| pubmed-article:16002669 | pubmed:author | pubmed-author:IngulliElizab... | lld:pubmed |
| pubmed-article:16002669 | pubmed:author | pubmed-author:BassoVeronica... | lld:pubmed |
| pubmed-article:16002669 | pubmed:author | pubmed-author:MondinoAnnaA | lld:pubmed |
| pubmed-article:16002669 | pubmed:author | pubmed-author:ZimmermannVal... | lld:pubmed |
| pubmed-article:16002669 | pubmed:author | pubmed-author:HuguesStephan... | lld:pubmed |
| pubmed-article:16002669 | pubmed:author | pubmed-author:RivinoLauraL | lld:pubmed |
| pubmed-article:16002669 | pubmed:author | pubmed-author:CasertaStefan... | lld:pubmed |
| pubmed-article:16002669 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16002669 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16002669 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:16002669 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16002669 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16002669 | pubmed:pagination | 739-48 | lld:pubmed |
| pubmed-article:16002669 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16002669 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16002669 | pubmed:articleTitle | Phenotype and homing of CD4 tumor-specific T cells is modulated by tumor bulk. | lld:pubmed |
| pubmed-article:16002669 | pubmed:affiliation | Cancer Immunotherapy and Gene Therapy Program, S. Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy. | lld:pubmed |
| pubmed-article:16002669 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16002669 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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