| pubmed-article:15999153 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15999153 | lifeskim:mentions | umls-concept:C1134719 | lld:lifeskim |
| pubmed-article:15999153 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:15999153 | lifeskim:mentions | umls-concept:C0877857 | lld:lifeskim |
| pubmed-article:15999153 | lifeskim:mentions | umls-concept:C0598666 | lld:lifeskim |
| pubmed-article:15999153 | lifeskim:mentions | umls-concept:C0457083 | lld:lifeskim |
| pubmed-article:15999153 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15999153 | pubmed:dateCreated | 2005-7-6 | lld:pubmed |
| pubmed-article:15999153 | pubmed:abstractText | A major focus of tumor immunology is to reveal the potential role and capacity of immunocompetent cells found in different solid tumor tissues. The most abundant infiltrating cells (TIL), the T lymphocytes have been investigated in details concerning T-cell receptor usage and specificity. However, B cells have hardly been investigated in this respect, although high cellular B-cell infiltration has been correlated with improved patients' survival in some breast carcinomas. This led to our objectives to study variable region gene usage of the tumor-infiltrating B cells in different breast carcinoma types. By defining the immunoglobulin repertoire of the tumor-infiltrating B lymphocytes in the most common invasive ductal carcinoma (IDC) of the breast we compared it to the rare medullary breast carcinoma (MBC). After phenotyping infiltrating ductal carcinomas, B cells were obtained from tumor tissue by microdissection technique. Numerous rearranged TIL-B immunoglobulin heavy chain V genes (VH) were amplified, cloned, sequenced, and comparatively analyzed. Some characteristics were found for both breast carcinoma types. The immunoglobulins produced by TIL-B in ductal carcinoma are highly matured and oligoclonal. We conclude that Ig variable region gene usage reveals similar and distinguishable characteristics of TIL-B immunoglobulin repertoires, which are representative of the nature of the immune responses in invasive ductal and medullary breast carcinomas. | lld:pubmed |
| pubmed-article:15999153 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15999153 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15999153 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15999153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15999153 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15999153 | pubmed:issn | 1219-4956 | lld:pubmed |
| pubmed-article:15999153 | pubmed:author | pubmed-author:TeillaudJean-... | lld:pubmed |
| pubmed-article:15999153 | pubmed:author | pubmed-author:TóthJózsefJ | lld:pubmed |
| pubmed-article:15999153 | pubmed:author | pubmed-author:KotlanBeatrix... | lld:pubmed |
| pubmed-article:15999153 | pubmed:author | pubmed-author:StottDavid... | lld:pubmed |
| pubmed-article:15999153 | pubmed:author | pubmed-author:SimsaPeterP | lld:pubmed |
| pubmed-article:15999153 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15999153 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:15999153 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15999153 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15999153 | pubmed:pagination | 92-7 | lld:pubmed |
| pubmed-article:15999153 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15999153 | pubmed:meshHeading | pubmed-meshheading:15999153... | lld:pubmed |
| pubmed-article:15999153 | pubmed:meshHeading | pubmed-meshheading:15999153... | lld:pubmed |
| pubmed-article:15999153 | pubmed:meshHeading | pubmed-meshheading:15999153... | lld:pubmed |
| pubmed-article:15999153 | pubmed:meshHeading | pubmed-meshheading:15999153... | lld:pubmed |
| pubmed-article:15999153 | pubmed:meshHeading | pubmed-meshheading:15999153... | lld:pubmed |
| pubmed-article:15999153 | pubmed:meshHeading | pubmed-meshheading:15999153... | lld:pubmed |
| pubmed-article:15999153 | pubmed:meshHeading | pubmed-meshheading:15999153... | lld:pubmed |
| pubmed-article:15999153 | pubmed:meshHeading | pubmed-meshheading:15999153... | lld:pubmed |
| pubmed-article:15999153 | pubmed:meshHeading | pubmed-meshheading:15999153... | lld:pubmed |
| pubmed-article:15999153 | pubmed:meshHeading | pubmed-meshheading:15999153... | lld:pubmed |
| pubmed-article:15999153 | pubmed:meshHeading | pubmed-meshheading:15999153... | lld:pubmed |
| pubmed-article:15999153 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15999153 | pubmed:articleTitle | Tumor-infiltrating B cell immunoglobulin variable region gene usage in invasive ductal breast carcinoma. | lld:pubmed |
| pubmed-article:15999153 | pubmed:affiliation | National Medical Center, Institute of Haematology and Immunology, Budapest, H-1135, Hungary. | lld:pubmed |
| pubmed-article:15999153 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15999153 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:15999153 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:15999153 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15999153 | lld:pubmed |
