| pubmed-article:15998719 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15998719 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:15998719 | lifeskim:mentions | umls-concept:C0020517 | lld:lifeskim |
| pubmed-article:15998719 | lifeskim:mentions | umls-concept:C0079429 | lld:lifeskim |
| pubmed-article:15998719 | lifeskim:mentions | umls-concept:C0815047 | lld:lifeskim |
| pubmed-article:15998719 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15998719 | pubmed:dateCreated | 2005-10-26 | lld:pubmed |
| pubmed-article:15998719 | pubmed:abstractText | The inhibitor of galactose catabolic (GAL) gene expression in Saccharomyces cerevisiae, Gal80p, interacts with the activator Gal4p and the signal transducer Gal3p and self-associates. Selection for loss of Gal80p inhibitor function yielded gal80 mutants at an extremely high rate. Out of these, 21 nonoverlapping point mutants were identified; each were due to a single-amino-acid exchange in conserved residues. Semiquantitative biochemical analysis of the corresponding mutant proteins revealed that each of the 21 amino acid alterations caused simultaneous defects in every single protein-protein interaction and in Gal80's structural integrity. Thus, Gal80 provides an unprecedented example for a protein's structural sensitivity to minimal sequence alterations. | lld:pubmed |
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| pubmed-article:15998719 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15998719 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15998719 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15998719 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15998719 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:15998719 | pubmed:author | pubmed-author:MelcherKarste... | lld:pubmed |
| pubmed-article:15998719 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15998719 | pubmed:volume | 171 | lld:pubmed |
| pubmed-article:15998719 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15998719 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15998719 | pubmed:pagination | 469-76 | lld:pubmed |
| pubmed-article:15998719 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15998719 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15998719 | pubmed:articleTitle | Mutational hypersensitivity of a gene regulatory protein: Saccharomyces cerevisiae Gal80p. | lld:pubmed |
| pubmed-article:15998719 | pubmed:affiliation | Institute of Microbiology, Biocenter Niederursel, Goethe University, Frankfurt, Germany. k.melcher@ulster.ac.uk | lld:pubmed |
| pubmed-article:15998719 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15998719 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15998719 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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