pubmed-article:15994288 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0376622 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C1704939 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0010711 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0011015 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0011900 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0449438 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0332287 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C1823242 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C0139121 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C1522609 | lld:lifeskim |
pubmed-article:15994288 | lifeskim:mentions | umls-concept:C1554112 | lld:lifeskim |
pubmed-article:15994288 | pubmed:issue | 8 | lld:pubmed |
pubmed-article:15994288 | pubmed:dateCreated | 2005-10-5 | lld:pubmed |
pubmed-article:15994288 | pubmed:abstractText | To determine whether MDR1 reversal by the addition of the P-glycoprotein (P-gp) inhibitor PSC-833 to standard induction chemotherapy would improve event-free survival (EFS), 419 untreated patients with acute myeloid leukemia (AML) aged 60 years and older were randomized to receive 2 induction cycles of daunorubicin and cytarabine with or without PSC-833. Patients in complete remission were then given 1 consolidation cycle without PSC-833. Neither complete response (CR) rate (54% versus 48%; P = .22), 5-year EFS (7% versus 8%; P = .53), disease-free survival (DFS; 13% versus 17%; P = .06) nor overall survival (OS; 10% in both arms; P = .52) were significantly improved in the PSC-833 arm. An integrated P-gp score (IPS) was determined based on P-gp function and P-gp expression in AML cells obtained prior to treatment. A higher IPS was associated with a significantly lower CR rate and worse EFS and OS. There was no significant interaction between IPS and treatment arm with respect to CR rate and survival, indicating also a lack of benefit of PSC-833 in P-gp-positive patients. The role of strategies aimed at inhibitory P-gp and other drug-resistance mechanisms continues to be defined in the treatment of patients with AML. | lld:pubmed |
pubmed-article:15994288 | pubmed:language | eng | lld:pubmed |
pubmed-article:15994288 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15994288 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:15994288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:15994288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15994288 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:15994288 | pubmed:month | Oct | lld:pubmed |
pubmed-article:15994288 | pubmed:issn | 0006-4971 | lld:pubmed |
pubmed-article:15994288 | pubmed:author | pubmed-author:PiccalugaPier... | lld:pubmed |
pubmed-article:15994288 | pubmed:author | pubmed-author:LöwenbergBobB | lld:pubmed |
pubmed-article:15994288 | pubmed:author | pubmed-author:CrumpMichaelM | lld:pubmed |
pubmed-article:15994288 | pubmed:author | pubmed-author:SonneveldPiet... | lld:pubmed |
pubmed-article:15994288 | pubmed:author | pubmed-author:VellengaEdoE | lld:pubmed |
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pubmed-article:15994288 | pubmed:author | pubmed-author:ShepherdJohnJ | lld:pubmed |
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pubmed-article:15994288 | pubmed:author | pubmed-author:KnaufWolfgang... | lld:pubmed |
pubmed-article:15994288 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:15994288 | pubmed:day | 15 | lld:pubmed |
pubmed-article:15994288 | pubmed:volume | 106 | lld:pubmed |
pubmed-article:15994288 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:15994288 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:15994288 | pubmed:pagination | 2646-54 | lld:pubmed |
pubmed-article:15994288 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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pubmed-article:15994288 | pubmed:year | 2005 | lld:pubmed |
pubmed-article:15994288 | pubmed:articleTitle | The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis. | lld:pubmed |
pubmed-article:15994288 | pubmed:affiliation | Department of Hematology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. p.sonneveld@erasmusmc.nl. | lld:pubmed |
pubmed-article:15994288 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:15994288 | pubmed:publicationType | Clinical Trial | lld:pubmed |
pubmed-article:15994288 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
pubmed-article:15994288 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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