| pubmed-article:15994022 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15994022 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:15994022 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:15994022 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
| pubmed-article:15994022 | lifeskim:mentions | umls-concept:C0152350 | lld:lifeskim |
| pubmed-article:15994022 | lifeskim:mentions | umls-concept:C0065898 | lld:lifeskim |
| pubmed-article:15994022 | lifeskim:mentions | umls-concept:C1113688 | lld:lifeskim |
| pubmed-article:15994022 | lifeskim:mentions | umls-concept:C1415500 | lld:lifeskim |
| pubmed-article:15994022 | lifeskim:mentions | umls-concept:C1709701 | lld:lifeskim |
| pubmed-article:15994022 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15994022 | pubmed:dateCreated | 2005-8-15 | lld:pubmed |
| pubmed-article:15994022 | pubmed:abstractText | The hypocretins (Hcrt; also known as orexins) and melanin-concentrating hormone comprise distinct families of neuropeptides synthesized in cells located in the lateral hypothalamus and adjacent areas. The Hcrts are thought to modulate food intake and sleep/wake patterns in mammals. Melanin-concentrating hormone has a well-documented role in energy metabolism. A moderate plexus of Hcrt immunoreactive terminals has been described in the hamster intergeniculate leaflet, part of the circadian rhythm system. This study investigated the origin of Hcrt-immunoreactive terminals in the intergeniculate leaflet and determined whether melanin-concentrating hormone neurons also project to the intergeniculate leaflet. The tracer, cholera toxin beta-subunit, was injected into the intergeniculate leaflet of the golden hamster. Double-label fluorescent immunohistochemistry for cholera toxin beta-subunit and Hcrt or melanin-concentrating hormone was then performed to identify retrogradely labeled cells also containing immunoreactive peptide. Most cholera toxin beta-subunit-labeled cells were detected in the medial zona incerta and sub-incertal zone, with few observed in the lateral hypothalamus. Hcrt-immunoreactive cells were abundant and found largely in the lateral hypothalamus and adjacent nuclei. Melanin-concentrating hormone cells were also abundant in the medial zona incerta, in close proximity to cholera toxin beta-subunit-labeled cells, but ventral to them. Cells containing both cholera toxin beta-subunit and Hcrt-immunoreactive, were present in the dorsal aspect of the lateral hypothalamus. The number observed was small, < or = 1% of the total number of Hcrt cells counted in the hamster. No cholera toxin beta-subunit-immunoreactive cells also contained melanin-concentrating hormone and no melanin-concentrating hormone-immunoreactive processes were evident in the intergeniculate leaflet. The results show that a small number of lateral hypothalamus cells containing Hcrt-immunoreactivity project to the intergeniculate leaflet, but they are scattered rather than collected into a discrete group. At the present time there is no information regarding the function of these cells, although they may contribute to the regulation of sleep/arousal, circadian rhythmicity, or vestibulo-oculomotor function. | lld:pubmed |
| pubmed-article:15994022 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15994022 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15994022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994022 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15994022 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:15994022 | pubmed:author | pubmed-author:BlanchardJJ | lld:pubmed |
| pubmed-article:15994022 | pubmed:author | pubmed-author:VidalLL | lld:pubmed |
| pubmed-article:15994022 | pubmed:author | pubmed-author:MorinL PLP | lld:pubmed |
| pubmed-article:15994022 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15994022 | pubmed:volume | 134 | lld:pubmed |
| pubmed-article:15994022 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15994022 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15994022 | pubmed:pagination | 1081-90 | lld:pubmed |
| pubmed-article:15994022 | pubmed:dateRevised | 2011-3-8 | lld:pubmed |
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| pubmed-article:15994022 | pubmed:meshHeading | pubmed-meshheading:15994022... | lld:pubmed |
| pubmed-article:15994022 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15994022 | pubmed:articleTitle | Hypothalamic and zona incerta neurons expressing hypocretin, but not melanin concentrating hormone, project to the hamster intergeniculate leaflet. | lld:pubmed |
| pubmed-article:15994022 | pubmed:affiliation | Department of Psychiatry and Behavioral Sciences, Health Sciences Center, Stony Brook University, Stony Brook, NY 11794-8101, USA. | lld:pubmed |
| pubmed-article:15994022 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15994022 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15994022 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15994022 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
