| pubmed-article:15991837 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15991837 | lifeskim:mentions | umls-concept:C0031110 | lld:lifeskim |
| pubmed-article:15991837 | lifeskim:mentions | umls-concept:C0040184 | lld:lifeskim |
| pubmed-article:15991837 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:15991837 | lifeskim:mentions | umls-concept:C0033785 | lld:lifeskim |
| pubmed-article:15991837 | lifeskim:mentions | umls-concept:C1744681 | lld:lifeskim |
| pubmed-article:15991837 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:15991837 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:15991837 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15991837 | pubmed:dateCreated | 2005-7-4 | lld:pubmed |
| pubmed-article:15991837 | pubmed:abstractText | The etiology and the pathogenesis of congenital pseudarthrosis of the tibia (CPT) are still unknown. The affected tibia exhibits insufficient mechanical strength and osteogenetic capability. CPT is frequently associated with neurofibromatosis type 1 (NF1; von Recklinghausen's disease); however, both diseases have not yet been linked pathogenetically. This study presents the pathomorphologic findings of CPT under special consideration of NF1. Therefore, samples from patients operated on for CPT (n = 4) with (n = 3) and without (n = 1) neurofibromatosis were investigated by light microscopy, immunohistochemistry, and electron microscopy. The most striking finding in all patients was thickened periosteum with accumulation of nerval cells surrounding small arteries, causing subtotal or complete obliteration. In conclusion, impaired vascularization can result in decreased osteogenic capabilities. The similarity of ultrastructural findings in the abnormal periosteum and in skin neurofibromas of neurofibromatosis patients may indicate a pathogenetic association of both diseases. | lld:pubmed |
| pubmed-article:15991837 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15991837 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15991837 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15991837 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15991837 | pubmed:issn | 0344-0338 | lld:pubmed |
| pubmed-article:15991837 | pubmed:author | pubmed-author:Klosterhalfen... | lld:pubmed |
| pubmed-article:15991837 | pubmed:author | pubmed-author:WeberMichaelM | lld:pubmed |
| pubmed-article:15991837 | pubmed:author | pubmed-author:SenderekJanJ | lld:pubmed |
| pubmed-article:15991837 | pubmed:author | pubmed-author:BüttnerReinha... | lld:pubmed |
| pubmed-article:15991837 | pubmed:author | pubmed-author:FüzesiLaszloL | lld:pubmed |
| pubmed-article:15991837 | pubmed:author | pubmed-author:AlferJoachimJ | lld:pubmed |
| pubmed-article:15991837 | pubmed:author | pubmed-author:Hermanns-Sach... | lld:pubmed |
| pubmed-article:15991837 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15991837 | pubmed:volume | 201 | lld:pubmed |
| pubmed-article:15991837 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15991837 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15991837 | pubmed:pagination | 305-12 | lld:pubmed |
| pubmed-article:15991837 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:meshHeading | pubmed-meshheading:15991837... | lld:pubmed |
| pubmed-article:15991837 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15991837 | pubmed:articleTitle | Vascular changes in the periosteum of congenital pseudarthrosis of the tibia. | lld:pubmed |
| pubmed-article:15991837 | pubmed:affiliation | Institute of Pathology, University Hospital, RWTH Aachen, Pauwelsstr. 30, D-52057 Aachen, Germany. hermanns@ukaachen.de | lld:pubmed |
| pubmed-article:15991837 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15991837 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15991837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15991837 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15991837 | lld:pubmed |
