| pubmed-article:15990946 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15990946 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:15990946 | lifeskim:mentions | umls-concept:C0020538 | lld:lifeskim |
| pubmed-article:15990946 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:15990946 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:15990946 | lifeskim:mentions | umls-concept:C0132555 | lld:lifeskim |
| pubmed-article:15990946 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:15990946 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:15990946 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15990946 | pubmed:dateCreated | 2006-2-20 | lld:pubmed |
| pubmed-article:15990946 | pubmed:abstractText | Nitric oxide (NO*) plays an important role in various physiological processes. The aim of the present study was to investigate if brain mitochondrial nitric oxide synthase (mtNOS) is active and functional during hypertension. L-citrulline production, an indicator of nitric oxide synthesis, was concentration-dependent on L-arginine in all strains and all ages tested, and was inhibited by 7-Nitroindazole (7-NI). Brain mitochondria of 1 month-old (prehypertensive) spontaneously hypertensive rats (SHR) exhibited a significantly (p < 0.05) low basal L-citrulline content as compared to age-matched Wistar (W) and Wistar-Kyoto (WKY) rats. L-citrulline synthesis in SHR rats showed a significant (p < 0.01) low response to L-arginine in 3 and 7 months-old rats. Respiratory rates in states 3 and 4 increased with low L-arginine concentration in all strains and all ages. The results suggest that in rat brain mitochondria, L-citrulline synthesis is constant once age-related hypertension is installed and NO* does not regulate oxidative phosphorylation. | lld:pubmed |
| pubmed-article:15990946 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15990946 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15990946 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15990946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15990946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15990946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15990946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15990946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15990946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15990946 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15990946 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15990946 | pubmed:issn | 0939-4451 | lld:pubmed |
| pubmed-article:15990946 | pubmed:author | pubmed-author:Villalobos-Mo... | lld:pubmed |
| pubmed-article:15990946 | pubmed:author | pubmed-author:Saavedra-Moli... | lld:pubmed |
| pubmed-article:15990946 | pubmed:author | pubmed-author:Clemente-Guer... | lld:pubmed |
| pubmed-article:15990946 | pubmed:author | pubmed-author:Cortés-RojoCC | lld:pubmed |
| pubmed-article:15990946 | pubmed:author | pubmed-author:Calderón-Cort... | lld:pubmed |
| pubmed-article:15990946 | pubmed:author | pubmed-author:Sierra-Campos... | lld:pubmed |
| pubmed-article:15990946 | pubmed:author | pubmed-author:Gaona-Zamudio... | lld:pubmed |
| pubmed-article:15990946 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15990946 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:15990946 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15990946 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15990946 | pubmed:pagination | 73-80 | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:meshHeading | pubmed-meshheading:15990946... | lld:pubmed |
| pubmed-article:15990946 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:15990946 | pubmed:articleTitle | Functional characterization of brain mitochondrial nitric oxide synthase during hypertension and aging. | lld:pubmed |
| pubmed-article:15990946 | pubmed:affiliation | Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich. México. | lld:pubmed |
| pubmed-article:15990946 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15990946 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:24598 | entrezgene:pubmed | pubmed-article:15990946 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15990946 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15990946 | lld:pubmed |
