| pubmed-article:15987158 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15987158 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:15987158 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:15987158 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:15987158 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:15987158 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:15987158 | lifeskim:mentions | umls-concept:C1173899 | lld:lifeskim |
| pubmed-article:15987158 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:15987158 | pubmed:dateCreated | 2005-6-30 | lld:pubmed |
| pubmed-article:15987158 | pubmed:abstractText | [structure: see text] (-)-16-Normethyldictyostatin has been made by total synthesis and is a potent antitumor agent in cells expressing wild-type tubulin and in one mutant cell line that is resistant to paclitaxel, but it is much less active than dictyostatin in another paclitaxel-resistant cell line where Val is substituted for Phe270. This provides strong evidence that the C16 methyl group of the dictyostatins is oriented toward Phe270 in the paclitaxel-binding site on beta-tubulin. | lld:pubmed |
| pubmed-article:15987158 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987158 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15987158 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987158 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15987158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15987158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987158 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15987158 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15987158 | pubmed:issn | 1523-7060 | lld:pubmed |
| pubmed-article:15987158 | pubmed:author | pubmed-author:CurranDennis... | lld:pubmed |
| pubmed-article:15987158 | pubmed:author | pubmed-author:BalachandranR... | lld:pubmed |
| pubmed-article:15987158 | pubmed:author | pubmed-author:DayBilly WBW | lld:pubmed |
| pubmed-article:15987158 | pubmed:author | pubmed-author:EdlerMichael... | lld:pubmed |
| pubmed-article:15987158 | pubmed:author | pubmed-author:HamelErnestE | lld:pubmed |
| pubmed-article:15987158 | pubmed:author | pubmed-author:ZhuGuangyuG | lld:pubmed |
| pubmed-article:15987158 | pubmed:author | pubmed-author:ShinYouseungY | lld:pubmed |
| pubmed-article:15987158 | pubmed:author | pubmed-author:MadirajuChari... | lld:pubmed |
| pubmed-article:15987158 | pubmed:author | pubmed-author:FournierJean-... | lld:pubmed |
| pubmed-article:15987158 | pubmed:author | pubmed-author:RaccorBrianne... | lld:pubmed |
| pubmed-article:15987158 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15987158 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:15987158 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:15987158 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15987158 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15987158 | pubmed:pagination | 2873-6 | lld:pubmed |
| pubmed-article:15987158 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15987158 | pubmed:meshHeading | pubmed-meshheading:15987158... | lld:pubmed |
| pubmed-article:15987158 | pubmed:meshHeading | pubmed-meshheading:15987158... | lld:pubmed |
| pubmed-article:15987158 | pubmed:meshHeading | pubmed-meshheading:15987158... | lld:pubmed |
| pubmed-article:15987158 | pubmed:meshHeading | pubmed-meshheading:15987158... | lld:pubmed |
| pubmed-article:15987158 | pubmed:meshHeading | pubmed-meshheading:15987158... | lld:pubmed |
| pubmed-article:15987158 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15987158 | pubmed:articleTitle | Synthesis and biological evaluation of (-)-16-normethyldictyostatin: a potent analogue of (-)-dictyostatin. | lld:pubmed |
| pubmed-article:15987158 | pubmed:affiliation | Department of Chemistry, University of Pittsburgh, Pennsylvania 15261, USA. | lld:pubmed |
| pubmed-article:15987158 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15987158 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15987158 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15987158 | lld:pubmed |
