| pubmed-article:15973410 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15973410 | lifeskim:mentions | umls-concept:C1172779 | lld:lifeskim |
| pubmed-article:15973410 | lifeskim:mentions | umls-concept:C0002766 | lld:lifeskim |
| pubmed-article:15973410 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:15973410 | pubmed:issue | 7045 | lld:pubmed |
| pubmed-article:15973410 | pubmed:dateCreated | 2005-6-23 | lld:pubmed |
| pubmed-article:15973410 | pubmed:abstractText | Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid mechanisms. Here we show that an opioid-independent form of this phenomenon, termed stress-induced analgesia, is mediated by the release of endogenous marijuana-like (cannabinoid) compounds in the brain. Blockade of cannabinoid CB(1) receptors in the periaqueductal grey matter of the midbrain prevents non-opioid stress-induced analgesia. In this region, stress elicits the rapid formation of two endogenous cannabinoids, the lipids 2-arachidonoylglycerol (2-AG) and anandamide. A newly developed inhibitor of the 2-AG-deactivating enzyme, monoacylglycerol lipase, selectively increases 2-AG concentrations and, when injected into the periaqueductal grey matter, enhances stress-induced analgesia in a CB1-dependent manner. Inhibitors of the anandamide-deactivating enzyme fatty-acid amide hydrolase, which selectively elevate anandamide concentrations, exert similar effects. Our results indicate that the coordinated release of 2-AG and anandamide in the periaqueductal grey matter might mediate opioid-independent stress-induced analgesia. These studies also identify monoacylglycerol lipase as a previously unrecognized therapeutic target. | lld:pubmed |
| pubmed-article:15973410 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15973410 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15973410 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15973410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15973410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15973410 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15973410 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15973410 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:15973410 | pubmed:author | pubmed-author:MateoM CMC | lld:pubmed |
| pubmed-article:15973410 | pubmed:author | pubmed-author:DurantiAndrea... | lld:pubmed |
| pubmed-article:15973410 | pubmed:author | pubmed-author:TarziaGiorgio... | lld:pubmed |
| pubmed-article:15973410 | pubmed:author | pubmed-author:CrystalJonath... | lld:pubmed |
| pubmed-article:15973410 | pubmed:author | pubmed-author:KreyJocelyn... | lld:pubmed |
| pubmed-article:15973410 | pubmed:author | pubmed-author:WalkerJ... | lld:pubmed |
| pubmed-article:15973410 | pubmed:author | pubmed-author:PiomelliDanie... | lld:pubmed |
| pubmed-article:15973410 | pubmed:author | pubmed-author:HolmesPhilip... | lld:pubmed |
| pubmed-article:15973410 | pubmed:author | pubmed-author:FegleyDarrenD | lld:pubmed |
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| pubmed-article:15973410 | pubmed:author | pubmed-author:HohmannAndrea... | lld:pubmed |
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| pubmed-article:15973410 | pubmed:author | pubmed-author:BoltonNathan... | lld:pubmed |
| pubmed-article:15973410 | pubmed:author | pubmed-author:NeelyMark HMH | lld:pubmed |
| pubmed-article:15973410 | pubmed:author | pubmed-author:MangieriRegin... | lld:pubmed |
| pubmed-article:15973410 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15973410 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:15973410 | pubmed:volume | 435 | lld:pubmed |
| pubmed-article:15973410 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15973410 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15973410 | pubmed:pagination | 1108-12 | lld:pubmed |
| pubmed-article:15973410 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15973410 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15973410 | pubmed:articleTitle | An endocannabinoid mechanism for stress-induced analgesia. | lld:pubmed |
| pubmed-article:15973410 | pubmed:affiliation | Neuroscience and Behavior Program, Department of Psychology, The University of Georgia, Athens, Georgia 30602-3013, USA. ahohmann@uga.edu | lld:pubmed |
| pubmed-article:15973410 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15973410 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15973410 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15973410 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15973410 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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