| pubmed-article:15964790 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15964790 | lifeskim:mentions | umls-concept:C0020242 | lld:lifeskim |
| pubmed-article:15964790 | lifeskim:mentions | umls-concept:C0665341 | lld:lifeskim |
| pubmed-article:15964790 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:15964790 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:15964790 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:15964790 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:15964790 | pubmed:dateCreated | 2005-6-20 | lld:pubmed |
| pubmed-article:15964790 | pubmed:abstractText | Using chromatin immunoprecipitation assays, we studied the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated recruitment of the aryl hydrocarbon receptor (AhR) and several co-regulators to the CYP1A1 promoter. AhR displayed a time-dependent recruitment, reaching a peak at 75 min and maintaining promoter occupancy for the remainder of the time course. Recruitment of AhR was followed by TIF2/SRC2, which preceded CBP, histone H3 acetylation, and RNA polymerase II (RNAPII). Simultaneous recruitment to the enhancer and the TATA box region suggests the formation of a large multiprotein complex bridging the two promoter regions. Interestingly, estrogen receptor alpha (ERalpha) displayed a TCDD- and time-dependent recruitment to the CYP1A1 promoter, which was increased by co-treatment with estradiol. Transfection in HuH7 human liver cells confirmed previously reported ERalpha enhancement of AhR activity. In contrast, TCDD did not induce the recruitment of ERalpha to the estrogen-responsive pS2 promoter, and after 120 min of co-treatment with estradiol, ERalpha is still present on the CYP1A1 promoter but no longer at pS2. RNA interference studies with T47D cells support a role for ERalpha in TCDD-dependent CYP1A1 expression. Our data suggest that ERalpha acts as a coregulator of AhR-mediated transcriptional activation and that the recruitment of ERalpha by AhR represents a novel mechanism AhR-ERalpha cross talk. | lld:pubmed |
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| pubmed-article:15964790 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15964790 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15964790 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15964790 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15964790 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15964790 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15964790 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:15964790 | pubmed:author | pubmed-author:GustafssonJan... | lld:pubmed |
| pubmed-article:15964790 | pubmed:author | pubmed-author:WihlénBjörnB | lld:pubmed |
| pubmed-article:15964790 | pubmed:author | pubmed-author:MatthewsJason... | lld:pubmed |
| pubmed-article:15964790 | pubmed:author | pubmed-author:ThomsenJaneJ | lld:pubmed |
| pubmed-article:15964790 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15964790 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:15964790 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15964790 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15964790 | pubmed:pagination | 5317-28 | lld:pubmed |
| pubmed-article:15964790 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15964790 | pubmed:meshHeading | pubmed-meshheading:15964790... | lld:pubmed |
