| pubmed-article:15958572 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15958572 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:15958572 | lifeskim:mentions | umls-concept:C0027912 | lld:lifeskim |
| pubmed-article:15958572 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:15958572 | lifeskim:mentions | umls-concept:C1520113 | lld:lifeskim |
| pubmed-article:15958572 | lifeskim:mentions | umls-concept:C2610414 | lld:lifeskim |
| pubmed-article:15958572 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
| pubmed-article:15958572 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15958572 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15958572 | pubmed:dateCreated | 2005-6-16 | lld:pubmed |
| pubmed-article:15958572 | pubmed:abstractText | Protocadherin-PC (PCDH-PC) is a gene on the human Y chromosome that is selectively expressed in apoptosis- and hormone-resistant human prostate cancer cells. The protein encoded by PCDH-PC is cytoplasmically localized and has a small serine-rich domain in its COOH terminus that is homologous to the beta-catenin binding site of classical cadherins. Variants of prostate cancer cells that express PCDH-PC have high levels of nuclear beta-catenin protein and increased wnt-signaling. In this study, we show that transfection of human prostate cancer cells (LNCaP) with PCDH-PC or culture of these cells in androgen-free medium (a condition that up-regulates PCDH-PC expression) activates wnt signaling as assessed by nuclear accumulation of beta-catenin, increased expression of luciferase from a reporter vector promoted by Tcf binding elements and increased expression of wnt target genes. Moreover, LNCaP cells transfected with PCDH-PC or grown in androgen-free medium transdifferentiate to neuroendocrine-like cells marked by elevated expression of neuron-specific enolase and chromogranin-A. Neuroendocrine transdifferentiation was also observed when LNCaP cells were transfected by stabilized beta-catenin. Increased wnt signaling and neuroendocrine transdifferentiation of LNCaP cells induced by culture in androgen-free medium was suppressed by short interfering RNAs that target PCDH-PC as well as by dominant-negative Tcf or short interfering RNA against beta-catenin, supporting the hypothesis that increased expression of PCDH-PC is driving neuroendocrine transdifferentiation by activating wnt signaling. These findings have significant implications for the process through which prostate cancers progress to hormone resistance in humans. | lld:pubmed |
| pubmed-article:15958572 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15958572 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15958572 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15958572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15958572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15958572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15958572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15958572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15958572 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15958572 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15958572 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:15958572 | pubmed:author | pubmed-author:ChopinDominiq... | lld:pubmed |
| pubmed-article:15958572 | pubmed:author | pubmed-author:ButtyanRalphR | lld:pubmed |
| pubmed-article:15958572 | pubmed:author | pubmed-author:GuoYingluY | lld:pubmed |
| pubmed-article:15958572 | pubmed:author | pubmed-author:BensonMitchel... | lld:pubmed |
| pubmed-article:15958572 | pubmed:author | pubmed-author:KitajewskiJan... | lld:pubmed |
| pubmed-article:15958572 | pubmed:author | pubmed-author:VacherotFranc... | lld:pubmed |
| pubmed-article:15958572 | pubmed:author | pubmed-author:ChenMin-WeiMW | lld:pubmed |
| pubmed-article:15958572 | pubmed:author | pubmed-author:BemisDebra... | lld:pubmed |
| pubmed-article:15958572 | pubmed:author | pubmed-author:YangXuezhenX | lld:pubmed |
| pubmed-article:15958572 | pubmed:author | pubmed-author:TerryStephane... | lld:pubmed |
| pubmed-article:15958572 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15958572 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15958572 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:15958572 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15958572 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15958572 | pubmed:pagination | 5263-71 | lld:pubmed |
| pubmed-article:15958572 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15958572 | pubmed:meshHeading | pubmed-meshheading:15958572... | lld:pubmed |
| pubmed-article:15958572 | pubmed:meshHeading | pubmed-meshheading:15958572... | lld:pubmed |
| pubmed-article:15958572 | pubmed:meshHeading | pubmed-meshheading:15958572... | lld:pubmed |
| pubmed-article:15958572 | pubmed:meshHeading | pubmed-meshheading:15958572... | lld:pubmed |
| pubmed-article:15958572 | pubmed:meshHeading | pubmed-meshheading:15958572... | lld:pubmed |
| pubmed-article:15958572 | pubmed:meshHeading | pubmed-meshheading:15958572... | lld:pubmed |
| pubmed-article:15958572 | pubmed:meshHeading | pubmed-meshheading:15958572... | lld:pubmed |
| pubmed-article:15958572 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15958572 | pubmed:articleTitle | A human- and male-specific protocadherin that acts through the wnt signaling pathway to induce neuroendocrine transdifferentiation of prostate cancer cells. | lld:pubmed |
| pubmed-article:15958572 | pubmed:affiliation | Department of Urology, First Hospital, Peking University, Beijing, China. | lld:pubmed |
| pubmed-article:15958572 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15958572 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15958572 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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