| pubmed-article:15957257 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15957257 | lifeskim:mentions | umls-concept:C1524059 | lld:lifeskim |
| pubmed-article:15957257 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:15957257 | lifeskim:mentions | umls-concept:C1613377 | lld:lifeskim |
| pubmed-article:15957257 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15957257 | pubmed:dateCreated | 2005-6-16 | lld:pubmed |
| pubmed-article:15957257 | pubmed:abstractText | 4-O-Podophyllotoxinyl 12-hydroxyl-octadec-Z-9-enoate (PHEFE) is a structurally novel FA analog of podophyllotoxin. In the present study, in vitro effects of PHEFE on a panel of 60 human tumor cell lines and its potential modes of anticancer action were investigated. PHEFE exhibited strong growth-inhibitory action in a number of solid tumor cells in vitro. It did not inhibit tubulin polymerization as podophyllotoxin does; rather, it inhibited the catalytic activity of topoisomerase II. Flow cytometry and staining assay with 4,6-diamidine-2-phenylindole dihydrochloride showed that PHEFE blocked the cell cycle at the G2/M phase and induced apoptosis in HL-60 cells. These analyses suggest that PHEFE has promising anticancer characteristics that differ from podophyllotoxin and etoposide. | lld:pubmed |
| pubmed-article:15957257 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15957257 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15957257 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15957257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15957257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15957257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15957257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15957257 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15957257 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15957257 | pubmed:issn | 0024-4201 | lld:pubmed |
| pubmed-article:15957257 | pubmed:author | pubmed-author:KhanIkhlas... | lld:pubmed |
| pubmed-article:15957257 | pubmed:author | pubmed-author:WalkerLarry... | lld:pubmed |
| pubmed-article:15957257 | pubmed:author | pubmed-author:KhanShabana... | lld:pubmed |
| pubmed-article:15957257 | pubmed:author | pubmed-author:MustafaJamalJ | lld:pubmed |
| pubmed-article:15957257 | pubmed:author | pubmed-author:MaGuoyiG | lld:pubmed |
| pubmed-article:15957257 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15957257 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:15957257 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15957257 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15957257 | pubmed:pagination | 303-8 | lld:pubmed |
| pubmed-article:15957257 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15957257 | pubmed:meshHeading | pubmed-meshheading:15957257... | lld:pubmed |
| pubmed-article:15957257 | pubmed:meshHeading | pubmed-meshheading:15957257... | lld:pubmed |
| pubmed-article:15957257 | pubmed:meshHeading | pubmed-meshheading:15957257... | lld:pubmed |
| pubmed-article:15957257 | pubmed:meshHeading | pubmed-meshheading:15957257... | lld:pubmed |
| pubmed-article:15957257 | pubmed:meshHeading | pubmed-meshheading:15957257... | lld:pubmed |
| pubmed-article:15957257 | pubmed:meshHeading | pubmed-meshheading:15957257... | lld:pubmed |
| pubmed-article:15957257 | pubmed:meshHeading | pubmed-meshheading:15957257... | lld:pubmed |
| pubmed-article:15957257 | pubmed:meshHeading | pubmed-meshheading:15957257... | lld:pubmed |
| pubmed-article:15957257 | pubmed:meshHeading | pubmed-meshheading:15957257... | lld:pubmed |
| pubmed-article:15957257 | pubmed:meshHeading | pubmed-meshheading:15957257... | lld:pubmed |
| pubmed-article:15957257 | pubmed:meshHeading | pubmed-meshheading:15957257... | lld:pubmed |
| pubmed-article:15957257 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15957257 | pubmed:articleTitle | Anticancer activity and possible mode of action of 4-O-podophyllotoxinyl 12-hydroxyl-octadec-Z-9-enoate. | lld:pubmed |
| pubmed-article:15957257 | pubmed:affiliation | National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA. | lld:pubmed |
| pubmed-article:15957257 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15957257 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
