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pubmed-article:15956649pubmed:abstractTextThe epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib (also known as Tarceva or OSI-774) has shown promising response rates in malignant gliomas. We investigated the association between expression of EGFR and downstream signaling components and the response of malignant gliomas to erlotinib in a phase I trial of erlotinib administered either alone or with the alkylating agent temozolomide.lld:pubmed
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pubmed-article:15956649pubmed:articleTitleEpidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib.lld:pubmed
pubmed-article:15956649pubmed:affiliationDepartment of Neurosurgery, Brain Tumor Research Center, University of California-San Francisco, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143, USA. hkogan@radonc17.ucsf.edulld:pubmed
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