Linked Life Data

15953603

Source:http://linkedlifedata.com/resource/pubmed/id/15953603

Statements in which the resource exists.
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pubmed-article:15953603pubmed:abstractTextPhenobarbital (PB) induction of CYP2B, a representative target gene of constitutive androstane receptor (CAR), has been observed to be attenuated in preneoplastic lesions of rat liver; however, molecular basis for this attenuation is poorly understood. In this report, we provide evidence indicating that the CAR expressed in the hepatic preneoplastic lesions of rats and mice was resistant to nuclear translocation and transactivation of the PB-responsive enhancer module upon PB treatment. These observations suggest that the attenuation of the induction of CYP2B by PB in hepatic preneoplastic lesions is evidently a consequence of impaired nuclear translocation of CAR.lld:pubmed
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pubmed-article:15953603pubmed:articleTitleImpaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital.lld:pubmed
pubmed-article:15953603pubmed:affiliationDepartment of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8555, Japan. numazawa@pharm.showa-u.ac.jplld:pubmed
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