| pubmed-article:15953585 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15953585 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15953585 | lifeskim:mentions | umls-concept:C0596508 | lld:lifeskim |
| pubmed-article:15953585 | lifeskim:mentions | umls-concept:C0012929 | lld:lifeskim |
| pubmed-article:15953585 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:15953585 | lifeskim:mentions | umls-concept:C0206243 | lld:lifeskim |
| pubmed-article:15953585 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:15953585 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:15953585 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15953585 | pubmed:dateCreated | 2005-6-27 | lld:pubmed |
| pubmed-article:15953585 | pubmed:abstractText | In a previous study, we used mouse zygotes as recipients of mtDNA with a large-scale deletion mutation (DeltamtDNA) and generated respiration-deficient mice (mito-mice) carrying DeltamtDNA. In this study, we used mouse ES cells as recipients of DeltamtDNA, and generated mito-mice with DeltamtDNA only when the ES cells carried 17% DeltamtDNA. No chimera mice or their F(1) progenies were obtained from ES cells carrying more than 61% DeltamtDNA. These observations suggest that respiratory defects of ES cells inhibit their normal differentiation into chimera mice and mito-mice, and that ES cells are more effective than zygotes for generation of mito-mice carrying mtDNAs without significant pathogenic mutations. | lld:pubmed |
| pubmed-article:15953585 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15953585 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15953585 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15953585 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15953585 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15953585 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15953585 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15953585 | pubmed:author | pubmed-author:AizawaShinich... | lld:pubmed |
| pubmed-article:15953585 | pubmed:author | pubmed-author:WatanabeNaoki... | lld:pubmed |
| pubmed-article:15953585 | pubmed:author | pubmed-author:NakadaKazutoK | lld:pubmed |
| pubmed-article:15953585 | pubmed:author | pubmed-author:HayashiJun-Ic... | lld:pubmed |
| pubmed-article:15953585 | pubmed:author | pubmed-author:KasaharaAtsuk... | lld:pubmed |
| pubmed-article:15953585 | pubmed:author | pubmed-author:SudaYokoY | lld:pubmed |
| pubmed-article:15953585 | pubmed:author | pubmed-author:IshikawaKaori... | lld:pubmed |
| pubmed-article:15953585 | pubmed:author | pubmed-author:SatoAkitsuguA | lld:pubmed |
| pubmed-article:15953585 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15953585 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:15953585 | pubmed:volume | 333 | lld:pubmed |
| pubmed-article:15953585 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15953585 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15953585 | pubmed:pagination | 590-5 | lld:pubmed |
| pubmed-article:15953585 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:meshHeading | pubmed-meshheading:15953585... | lld:pubmed |
| pubmed-article:15953585 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15953585 | pubmed:articleTitle | Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion. | lld:pubmed |
| pubmed-article:15953585 | pubmed:affiliation | Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki 305-8572, Japan. | lld:pubmed |
| pubmed-article:15953585 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15953585 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
