| pubmed-article:15951332 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15951332 | lifeskim:mentions | umls-concept:C0029347 | lld:lifeskim |
| pubmed-article:15951332 | lifeskim:mentions | umls-concept:C0521346 | lld:lifeskim |
| pubmed-article:15951332 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:15951332 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15951332 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15951332 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15951332 | lifeskim:mentions | umls-concept:C0085416 | lld:lifeskim |
| pubmed-article:15951332 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15951332 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15951332 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:15951332 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15951332 | pubmed:dateCreated | 2005-9-8 | lld:pubmed |
| pubmed-article:15951332 | pubmed:abstractText | Oxidants and neutrophils contribute to lung injury during influenza A virus (IAV) infection. Surfactant protein (SP)-D plays a pivotal role in restricting IAV replication and inflammation in the first several days after infection. Despite its potent anti-inflammatory effects in vivo, preincubation of IAV with SP-D in vitro strongly increases neutrophil respiratory burst responses to the virus. Several factors are shown to modify this apparent proinflammatory effect of SP-D. Although multimeric forms of SP-D show dose-dependent augmentation of respiratory burst responses, trimeric, single-arm forms either show no effect or inhibit these responses. Furthermore, if neutrophils are preincubated with multimeric SP-D before IAV is added, oxidant responses to the virus are significantly reduced. The ability of SP-D to increase neutrophil uptake of IAV can be dissociated from enhancement of oxidant responses. Finally, several other innate immune proteins that bind to SP-D and/or IAV (i.e., SP-A, lung glycoprotein-340 or mucin) significantly reduce the ability of SP-D to promote neutrophil oxidant response. As a result, the net effect of bronchoalveolar lavage fluids is to increase neutrophil uptake of IAV while reducing the respiratory burst response to virus. | lld:pubmed |
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| pubmed-article:15951332 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15951332 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15951332 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15951332 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15951332 | pubmed:issn | 1040-0605 | lld:pubmed |
| pubmed-article:15951332 | pubmed:author | pubmed-author:CrouchErikaE | lld:pubmed |
| pubmed-article:15951332 | pubmed:author | pubmed-author:BatenburgJose... | lld:pubmed |
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| pubmed-article:15951332 | pubmed:author | pubmed-author:HartshornKeva... | lld:pubmed |
| pubmed-article:15951332 | pubmed:author | pubmed-author:HolmskovUffeU | lld:pubmed |
| pubmed-article:15951332 | pubmed:author | pubmed-author:WhiteMitchell... | lld:pubmed |
| pubmed-article:15951332 | pubmed:author | pubmed-author:Leth-LarsenRi... | lld:pubmed |
| pubmed-article:15951332 | pubmed:author | pubmed-author:VesonaJennyJ | lld:pubmed |
| pubmed-article:15951332 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15951332 | pubmed:volume | 289 | lld:pubmed |
| pubmed-article:15951332 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15951332 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15951332 | pubmed:pagination | L606-16 | lld:pubmed |
| pubmed-article:15951332 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15951332 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15951332 | pubmed:articleTitle | Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus. | lld:pubmed |
| pubmed-article:15951332 | pubmed:affiliation | Dept. of Medicine, Boston University School of Medicine, MA 02118, USA. | lld:pubmed |
| pubmed-article:15951332 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15951332 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15951332 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15951332 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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