| pubmed-article:15942125 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15942125 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:15942125 | lifeskim:mentions | umls-concept:C0227349 | lld:lifeskim |
| pubmed-article:15942125 | lifeskim:mentions | umls-concept:C0023992 | lld:lifeskim |
| pubmed-article:15942125 | lifeskim:mentions | umls-concept:C0039241 | lld:lifeskim |
| pubmed-article:15942125 | lifeskim:mentions | umls-concept:C1979804 | lld:lifeskim |
| pubmed-article:15942125 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
| pubmed-article:15942125 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15942125 | pubmed:dateCreated | 2005-6-20 | lld:pubmed |
| pubmed-article:15942125 | pubmed:abstractText | The effect of loperamide on tachykinin NK(2)- and NK(3)-receptor-mediated 5-HT outflow from guinea pig colonic mucosa was investigated in vitro. The selective tachykinin NK(2)-receptor agonist [beta-Ala(8)]-neurokinin A(4-10) (betaAla-NKA) or the selective NK(3)-receptor agonist senktide elicited an increase in 5-HT outflow from whole colonic strips, but not from mucosa-free muscle layer preparations. The enhancing effect of betaAla-NKA and senktide was prevented by the selective NK(2)-receptor antagonist GR94800 or the selective NK(3)-receptor antagonist SB222200. Loperamide concentration-dependently suppressed the senktide-evoked 5-HT outflow, but failed to affect the betaAla-NKA-evoked 5-HT outflow. The kappa-opioid receptor antagonist nor-binaltorphimine or the delta-opioid receptor antagonist naltrindole displaced the concentration-response curve for the suppressant action of loperamide to the right without significant depression of the maximum. However, the mu-opioid receptor antagonist CTOP did not affect the suppressant effect of loperamide. We concluded that the NK(3) receptor-triggered 5-HT release from colonic mucosa is suppressed by loperamide-sensitive mechanisms, whereas the NK(2)-receptor-triggered 5-HT release is loperamide-insensitive. Our data also suggest that the suppressant effect of loperamide is probably mediated by the activation of kappa- and delta-opioid receptors located on intrinsic neurons. | lld:pubmed |
| pubmed-article:15942125 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15942125 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15942125 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15942125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15942125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15942125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15942125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15942125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15942125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15942125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15942125 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15942125 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15942125 | pubmed:issn | 1347-8613 | lld:pubmed |
| pubmed-article:15942125 | pubmed:author | pubmed-author:IkedaMasashiM | lld:pubmed |
| pubmed-article:15942125 | pubmed:author | pubmed-author:KamikawaYuich... | lld:pubmed |
| pubmed-article:15942125 | pubmed:author | pubmed-author:KojimaShu-Ich... | lld:pubmed |
| pubmed-article:15942125 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15942125 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:15942125 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15942125 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15942125 | pubmed:pagination | 175-80 | lld:pubmed |
| pubmed-article:15942125 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15942125 | pubmed:meshHeading | pubmed-meshheading:15942125... | lld:pubmed |
| pubmed-article:15942125 | pubmed:meshHeading | pubmed-meshheading:15942125... | lld:pubmed |
| pubmed-article:15942125 | pubmed:meshHeading | pubmed-meshheading:15942125... | lld:pubmed |
| pubmed-article:15942125 | pubmed:meshHeading | pubmed-meshheading:15942125... | lld:pubmed |
| pubmed-article:15942125 | pubmed:meshHeading | pubmed-meshheading:15942125... | lld:pubmed |
| pubmed-article:15942125 | pubmed:meshHeading | pubmed-meshheading:15942125... | lld:pubmed |
| pubmed-article:15942125 | pubmed:meshHeading | pubmed-meshheading:15942125... | lld:pubmed |
| pubmed-article:15942125 | pubmed:meshHeading | pubmed-meshheading:15942125... | lld:pubmed |
| pubmed-article:15942125 | pubmed:meshHeading | pubmed-meshheading:15942125... | lld:pubmed |
| pubmed-article:15942125 | pubmed:meshHeading | pubmed-meshheading:15942125... | lld:pubmed |
| pubmed-article:15942125 | pubmed:meshHeading | pubmed-meshheading:15942125... | lld:pubmed |
| pubmed-article:15942125 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15942125 | pubmed:articleTitle | Loperamide inhibits tachykinin NK3-receptor-triggered serotonin release without affecting NK2-receptor-triggered serotonin release from guinea pig colonic mucosa. | lld:pubmed |
| pubmed-article:15942125 | pubmed:affiliation | Department of Pharmacology, Dokkyo University School of Medicine, Tochigi, Japan. s-kojima@dokkymed.ac.jp | lld:pubmed |
| pubmed-article:15942125 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15942125 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15942125 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15942125 | lld:pubmed |
