| pubmed-article:15940671 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15940671 | lifeskim:mentions | umls-concept:C0004651 | lld:lifeskim |
| pubmed-article:15940671 | lifeskim:mentions | umls-concept:C0017349 | lld:lifeskim |
| pubmed-article:15940671 | lifeskim:mentions | umls-concept:C1185625 | lld:lifeskim |
| pubmed-article:15940671 | lifeskim:mentions | umls-concept:C0014239 | lld:lifeskim |
| pubmed-article:15940671 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:15940671 | lifeskim:mentions | umls-concept:C1257986 | lld:lifeskim |
| pubmed-article:15940671 | lifeskim:mentions | umls-concept:C0597177 | lld:lifeskim |
| pubmed-article:15940671 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15940671 | pubmed:dateCreated | 2005-7-6 | lld:pubmed |
| pubmed-article:15940671 | pubmed:abstractText | It has been shown that exogenous antigens can access the MHC class I pathway of professional antigen-processing cells. However, details as to how the MHC class I-peptide complex forms in the presentation pathway are still poorly understood. Here we used MHC class I-peptide-specific antibodies to investigate the formation and intracellular location of class I-peptide complexes in macrophages. We observed that the formation of class I-peptide complexes occurs within a few hours and lasts for another few hours on the cell surface of macrophages following loading with filamentous phage particles. The class I-peptide complexes in the process were co-localized with MHC class II molecules and endocytic system markers. Moreover, endosomal compartments containing class I-peptide complexes were found within intracellular organelles stained by DiOC6 and calnexin. In addition, the cross-presentation of phage particles was transporter associated with antigen processing (TAP)-dependent and sensitive to proteasome inhibitors and NH(4)Cl. These data suggest that endocytosed phage particles may be processed and cross-presented in organelles positive for phagosome and endoplasmic reticulum (ER) markers via a classical ER MHC class I loading mechanism. | lld:pubmed |
| pubmed-article:15940671 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15940671 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15940671 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15940671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15940671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15940671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15940671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15940671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15940671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15940671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15940671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15940671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15940671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15940671 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15940671 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15940671 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:15940671 | pubmed:author | pubmed-author:WuYuzhangY | lld:pubmed |
| pubmed-article:15940671 | pubmed:author | pubmed-author:ZhaoJianpingJ | lld:pubmed |
| pubmed-article:15940671 | pubmed:author | pubmed-author:BianJiangJ | lld:pubmed |
| pubmed-article:15940671 | pubmed:author | pubmed-author:ZhouWeiW | lld:pubmed |
| pubmed-article:15940671 | pubmed:author | pubmed-author:WanYingY | lld:pubmed |
| pubmed-article:15940671 | pubmed:author | pubmed-author:JiaZhengcaiZ | lld:pubmed |
| pubmed-article:15940671 | pubmed:author | pubmed-author:EngbergJanJ | lld:pubmed |
| pubmed-article:15940671 | pubmed:author | pubmed-author:ZouLiyunL | lld:pubmed |
| pubmed-article:15940671 | pubmed:author | pubmed-author:ZhouJingranJ | lld:pubmed |
| pubmed-article:15940671 | pubmed:author | pubmed-author:LiangYunfeiY | lld:pubmed |
| pubmed-article:15940671 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15940671 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:15940671 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15940671 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15940671 | pubmed:pagination | 2041-50 | lld:pubmed |
| pubmed-article:15940671 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15940671 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15940671 | pubmed:articleTitle | Cross-presentation of phage particle antigen in MHC class II and endoplasmic reticulum marker-positive compartments. | lld:pubmed |
| pubmed-article:15940671 | pubmed:affiliation | The Institute of Immunology, PLA, The Third Military Medical University, Shapingba District, Chongqing, PR China. | lld:pubmed |
| pubmed-article:15940671 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15940671 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
