| pubmed-article:15937958 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15937958 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:15937958 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15937958 | lifeskim:mentions | umls-concept:C1302401 | lld:lifeskim |
| pubmed-article:15937958 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:15937958 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:15937958 | lifeskim:mentions | umls-concept:C0237753 | lld:lifeskim |
| pubmed-article:15937958 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:15937958 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:15937958 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:15937958 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:15937958 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15937958 | pubmed:dateCreated | 2005-8-1 | lld:pubmed |
| pubmed-article:15937958 | pubmed:abstractText | The relevance of the Apc(+/Min) mouse model in the study of human colorectal cancer remains uncertain due to the predominance of small intestinal adenomas and few, if any, colorectal adenomas. A new strain of Apc(+/Min) mice (Apc(+/Min-FCCC)) with significantly greater numbers of colorectal adenomas has been generated and characterized. Male C57BL/6J-Apc(+/Min) mice (the Jackson Laboratory, Bar Harbor, ME) were crossed with wild-type (Apc(+/+)) C57BL/6J females from an independent colony at this institution (offspring=Apc(+/Min-FCCC)) and 233 animals were evaluated over 20 generations. In order to determine the contribution of genetics to the enhanced colorectal adenoma phenotype, breeding pairs (Apc(+/Min) male x wild type female C57BL/6J) were purchased from the Jackson Laboratory and offspring (Apc(+/Min-JAX)) were maintained in our facility under identical conditions (n=98). Animals were fed Purina Rodent chow (#5013) diet containing 5% fat. The entire intestinal tract was examined histopathologically in both strains. Both the Apc and Pla2g2a (candidate for Mom1) genes were sequenced and found to be identical for both the Apc(+/Min-FCCC) and Apc(+/Min-JAX) mouse strains. The multiplicity of colorectal adenomas in the Apc(+/Min-FCCC) mice was much higher than reported in the literature and significantly greater than the multiplicity of colorectal adenomas in Apc(+/Min-JAX) mice maintained in our facility (P=0.01). Apc(+/Min-FCCC) had a significantly greater incidence of rectal prolapse (P = 0.02) and small intestinal adenocarcinomes (P=0.001), and multiplicity of small intestinal adenocarcinomas (P=0.001) compared to Apc(+/Min-JAX) mice. Male Apc(+/Min-FCCC) mice had significantly greater numbers of colorectal adenomas compared to female Apc(+/Min-FCCC) mice (P=0.0002), as did male Apc(+/Min-JAX) mice vs. female Apc(+/Min-JAX) mice (P< 0.0001). These results allow us to conclude: (1) Apc(+/Min-FCCC) mice are unique in that they develop significantly greater numbers of colorectal adenomas and small intestinal cancers, and a significantly greater incidence of small intestinal cancers and rectal prolapse than Apc(+/Min-JAX) mice. (2) This study represents the first report of a significant gender difference in multiplicity of colorectal adenomas. (3) Differences between Apc(+/Min-FCCC) and Apc(+/Min-JAX) mice in currently undefined genetic modifiers may contribute to the enhanced colorectal phenotype. (4) The Apc(+/Min-FCCC) strain is highly suited for the investigation of colorectal neoplastic disease and chemoprevention studies. | lld:pubmed |
| pubmed-article:15937958 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15937958 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15937958 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15937958 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15937958 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15937958 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15937958 | pubmed:issn | 0899-1987 | lld:pubmed |
| pubmed-article:15937958 | pubmed:author | pubmed-author:ClapperMargie... | lld:pubmed |
| pubmed-article:15937958 | pubmed:author | pubmed-author:WangHaoH | lld:pubmed |
| pubmed-article:15937958 | pubmed:author | pubmed-author:LitwinSamS | lld:pubmed |
| pubmed-article:15937958 | pubmed:author | pubmed-author:CooperHarry... | lld:pubmed |
| pubmed-article:15937958 | pubmed:author | pubmed-author:ChangWen-Chi... | lld:pubmed |
| pubmed-article:15937958 | pubmed:author | pubmed-author:CoudryRenataR | lld:pubmed |
| pubmed-article:15937958 | pubmed:author | pubmed-author:GaryMonique... | lld:pubmed |
| pubmed-article:15937958 | pubmed:author | pubmed-author:EverleyLynett... | lld:pubmed |
| pubmed-article:15937958 | pubmed:author | pubmed-author:SpittleCynthi... | lld:pubmed |
| pubmed-article:15937958 | pubmed:copyrightInfo | (c) 2005 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:15937958 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15937958 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:15937958 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15937958 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15937958 | pubmed:pagination | 31-41 | lld:pubmed |
| pubmed-article:15937958 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15937958 | pubmed:meshHeading | pubmed-meshheading:15937958... | lld:pubmed |
| pubmed-article:15937958 | pubmed:meshHeading | pubmed-meshheading:15937958... | lld:pubmed |
| pubmed-article:15937958 | pubmed:meshHeading | pubmed-meshheading:15937958... | lld:pubmed |
| pubmed-article:15937958 | pubmed:meshHeading | pubmed-meshheading:15937958... | lld:pubmed |
| pubmed-article:15937958 | pubmed:meshHeading | pubmed-meshheading:15937958... | lld:pubmed |
| pubmed-article:15937958 | pubmed:meshHeading | pubmed-meshheading:15937958... | lld:pubmed |
| pubmed-article:15937958 | pubmed:meshHeading | pubmed-meshheading:15937958... | lld:pubmed |
| pubmed-article:15937958 | pubmed:meshHeading | pubmed-meshheading:15937958... | lld:pubmed |
| pubmed-article:15937958 | pubmed:meshHeading | pubmed-meshheading:15937958... | lld:pubmed |
| pubmed-article:15937958 | pubmed:meshHeading | pubmed-meshheading:15937958... | lld:pubmed |
| pubmed-article:15937958 | pubmed:meshHeading | pubmed-meshheading:15937958... | lld:pubmed |
| pubmed-article:15937958 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15937958 | pubmed:articleTitle | Generation of a unique strain of multiple intestinal neoplasia (Apc(+/Min-FCCC)) mice with significantly increased numbers of colorectal adenomas. | lld:pubmed |
| pubmed-article:15937958 | pubmed:affiliation | Department of Pathology, Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. | lld:pubmed |
| pubmed-article:15937958 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15937958 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15937958 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:11789 | entrezgene:pubmed | pubmed-article:15937958 | lld:entrezgene |
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