| pubmed-article:15937483 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15937483 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:15937483 | lifeskim:mentions | umls-concept:C0044602 | lld:lifeskim |
| pubmed-article:15937483 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:15937483 | lifeskim:mentions | umls-concept:C0679079 | lld:lifeskim |
| pubmed-article:15937483 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15937483 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:15937483 | lifeskim:mentions | umls-concept:C1514918 | lld:lifeskim |
| pubmed-article:15937483 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:15937483 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:15937483 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:15937483 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15937483 | pubmed:dateCreated | 2005-9-1 | lld:pubmed |
| pubmed-article:15937483 | pubmed:abstractText | Memory retrieval is a dynamic aspect of memory formation that can be studied separately from other stages of memory processing. Although several signal transduction pathways including ERK/MAP kinase have been implicated in memory retrieval, the underlying signaling events are poorly defined. Here we report that re-exposure of mice to context after contextual training stimulates the activity of phosphatidylinositol 3 kinase (PI3K) in the hippocampus. Inhibition of PI3K activity in the hippocampus in vivo blocked contextual memory retrieval and extinction. Inhibitors of PI3K signaling also blocked increases in ERK/MAP kinase activity associated with memory retrieval. This suggests that PI3K activation in the hippocampus is critical for memory retrieval and is required for activation of ERK/MAP kinase during retrieval. | lld:pubmed |
| pubmed-article:15937483 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15937483 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15937483 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15937483 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15937483 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15937483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15937483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15937483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15937483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15937483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15937483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15937483 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15937483 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15937483 | pubmed:issn | 1097-6256 | lld:pubmed |
| pubmed-article:15937483 | pubmed:author | pubmed-author:StormDaniel... | lld:pubmed |
| pubmed-article:15937483 | pubmed:author | pubmed-author:ChenXiX | lld:pubmed |
| pubmed-article:15937483 | pubmed:author | pubmed-author:WangHongbingH | lld:pubmed |
| pubmed-article:15937483 | pubmed:author | pubmed-author:AthosJaimeJ | lld:pubmed |
| pubmed-article:15937483 | pubmed:author | pubmed-author:GarelickMicha... | lld:pubmed |
| pubmed-article:15937483 | pubmed:author | pubmed-author:LilVickyV | lld:pubmed |
| pubmed-article:15937483 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15937483 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:15937483 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15937483 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15937483 | pubmed:pagination | 925-31 | lld:pubmed |
| pubmed-article:15937483 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15937483 | pubmed:meshHeading | pubmed-meshheading:15937483... | lld:pubmed |
| pubmed-article:15937483 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15937483 | pubmed:articleTitle | PI3 kinase signaling is required for retrieval and extinction of contextual memory. | lld:pubmed |
| pubmed-article:15937483 | pubmed:affiliation | Department of Pharmacology, University of Washington, Box 357280, Seattle, Washington 98195-7280, USA. | lld:pubmed |
| pubmed-article:15937483 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15937483 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15937483 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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