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pubmed-article:15930755pubmed:dateCreated2005-6-2lld:pubmed
pubmed-article:15930755pubmed:abstractTextThe isolation and characterization of rat lens aldose reductase (RLAR) inhibitors from the fruiting bodies of Ganoderma applanatum were conducted. Among the extracts and fractions from G. applanatum tested, the MeOH extract and EtOAc fraction were found to exhibit potent RLAR inhibition in vitro, their IC50 being 1.7 and 0.8 microg/ml, respectively. From the active EtOAc fraction, seven compounds with diverse structural moieties were isolated and identified as D-mannitol (1), 2-methoxyfatty acids (2), cerebrosides (3), daucosterol (4), 2,5-dihydroxyacetophenone (5), 2,5-dihydroxybenzoic acid (6), and protocatechualdehyde (7). Among them, protocatechualdehyde (7) was found to be the most potent RLAR inhibitor (IC50=0.7 microg/ml), and may be useful for the prevention and/or treatment of diabetic complications.lld:pubmed
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pubmed-article:15930755pubmed:statusMEDLINElld:pubmed
pubmed-article:15930755pubmed:monthJunlld:pubmed
pubmed-article:15930755pubmed:issn0918-6158lld:pubmed
pubmed-article:15930755pubmed:authorpubmed-author:ShinKuk...lld:pubmed
pubmed-article:15930755pubmed:authorpubmed-author:KangSam SikSSlld:pubmed
pubmed-article:15930755pubmed:authorpubmed-author:LeeSanghyunSlld:pubmed
pubmed-article:15930755pubmed:authorpubmed-author:ShimSang...lld:pubmed
pubmed-article:15930755pubmed:authorpubmed-author:KimJu SunJSlld:pubmed
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pubmed-article:15930755pubmed:volume28lld:pubmed
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pubmed-article:15930755pubmed:pagination1103-5lld:pubmed
pubmed-article:15930755pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15930755pubmed:year2005lld:pubmed
pubmed-article:15930755pubmed:articleTitleAldose reductase inhibitors from the fruiting bodies of Ganoderma applanatum.lld:pubmed
pubmed-article:15930755pubmed:affiliationNatural Products Research Institute and College of Pharmacy, Seoul National University, Japan.lld:pubmed
pubmed-article:15930755pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15930755pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:15930755pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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