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pubmed-article:15921909pubmed:abstractTextThe GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function. GDIs control the access of Rho GTPases to regulatory guanine nucleotide exchange factors and GTPase-activating proteins, to effector targets and to membranes where such effectors reside. We discuss here our current understanding of how Rho GTPase-GDI complexes are regulated by various proteins, lipids and enzymes that exert GDI displacement activity. We propose that phosphorylation mediated by diverse kinases might provide a means of controlling and coordinating Rho GTPase activation.lld:pubmed
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pubmed-article:15921909pubmed:articleTitleGDIs: central regulatory molecules in Rho GTPase activation.lld:pubmed
pubmed-article:15921909pubmed:affiliationDepartments of Immunology and Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.lld:pubmed
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