| pubmed-article:15920913 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15920913 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
| pubmed-article:15920913 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:15920913 | lifeskim:mentions | umls-concept:C0278488 | lld:lifeskim |
| pubmed-article:15920913 | lifeskim:mentions | umls-concept:C0332174 | lld:lifeskim |
| pubmed-article:15920913 | lifeskim:mentions | umls-concept:C0246415 | lld:lifeskim |
| pubmed-article:15920913 | lifeskim:mentions | umls-concept:C0086960 | lld:lifeskim |
| pubmed-article:15920913 | lifeskim:mentions | umls-concept:C1705187 | lld:lifeskim |
| pubmed-article:15920913 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:15920913 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15920913 | pubmed:dateCreated | 2005-5-30 | lld:pubmed |
| pubmed-article:15920913 | pubmed:abstractText | Standard dose docetaxel is burdened by severe toxicity. Weekly schedules have been shown to be active as standard scheme with reduced side effects. In 20-30% of elderly patients (pts) the classic 6-week schedule induces grade 3/4 fatigue and other cumulative toxicities. We carried out this safety study in order to evaluate whether a modified weekly docetaxel schedule would improve the toxicity profile. Twenty-one untreated elderly (> or = 70 years) pts suffering from metastatic breast cancer were enrolled in the study. Pts were treated with a weekly dose of 35 mg/m2 docetaxel for 6 weeks, followed by a 2-week rest. Further cycles were performed with this modified schedule: docetaxel days 1, 8 and 15 every 29 days. All pts received at least the first cycle (6 weeks). A total of 261 doses were delivered. No toxic deaths occurred. The toxicity was mild: we recorded 1 episode of grade 3 neutropenia and severe asthenia in only 2 pts (10%). We recorded an overall response rate of 33% (1 CR, 6 PR). Our data showed a reduced incidence of severe asthenia (2/21), obtained with a light modification of a weekly docetaxel schedule. | lld:pubmed |
| pubmed-article:15920913 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15920913 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15920913 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15920913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15920913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15920913 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15920913 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15920913 | pubmed:issn | 1120-009X | lld:pubmed |
| pubmed-article:15920913 | pubmed:author | pubmed-author:MarxPP | lld:pubmed |
| pubmed-article:15920913 | pubmed:author | pubmed-author:La TorreFF | lld:pubmed |
| pubmed-article:15920913 | pubmed:author | pubmed-author:CarboniRR | lld:pubmed |
| pubmed-article:15920913 | pubmed:author | pubmed-author:PicciottoMM | lld:pubmed |
| pubmed-article:15920913 | pubmed:author | pubmed-author:CaristiNN | lld:pubmed |
| pubmed-article:15920913 | pubmed:author | pubmed-author:MaisanoRR | lld:pubmed |
| pubmed-article:15920913 | pubmed:author | pubmed-author:ChiofaloGG | lld:pubmed |
| pubmed-article:15920913 | pubmed:author | pubmed-author:MafoddaAA | lld:pubmed |
| pubmed-article:15920913 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15920913 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:15920913 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15920913 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15920913 | pubmed:pagination | 242-6 | lld:pubmed |
| pubmed-article:15920913 | pubmed:dateRevised | 2009-8-4 | lld:pubmed |
| pubmed-article:15920913 | pubmed:meshHeading | pubmed-meshheading:15920913... | lld:pubmed |
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| pubmed-article:15920913 | pubmed:meshHeading | pubmed-meshheading:15920913... | lld:pubmed |
| pubmed-article:15920913 | pubmed:meshHeading | pubmed-meshheading:15920913... | lld:pubmed |
| pubmed-article:15920913 | pubmed:meshHeading | pubmed-meshheading:15920913... | lld:pubmed |
| pubmed-article:15920913 | pubmed:meshHeading | pubmed-meshheading:15920913... | lld:pubmed |
| pubmed-article:15920913 | pubmed:meshHeading | pubmed-meshheading:15920913... | lld:pubmed |
| pubmed-article:15920913 | pubmed:meshHeading | pubmed-meshheading:15920913... | lld:pubmed |
| pubmed-article:15920913 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15920913 | pubmed:articleTitle | A modified weekly docetaxel schedule as first-line chemotherapy in elderly metastatic breast cancer: a safety study. | lld:pubmed |
| pubmed-article:15920913 | pubmed:affiliation | Unità Operativa Complessa di Oncologia Medica, Azienda Ospedaliera Universitaria G. Martino Policlinico Messina Via Consolare Valeria, Gazzi, 98125 Messina, Italy. maisano@supereva.it | lld:pubmed |
| pubmed-article:15920913 | pubmed:publicationType | Journal Article | lld:pubmed |
