| pubmed-article:15920021 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15920021 | lifeskim:mentions | umls-concept:C0376466 | lld:lifeskim |
| pubmed-article:15920021 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:15920021 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:15920021 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:15920021 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15920021 | pubmed:dateCreated | 2005-6-24 | lld:pubmed |
| pubmed-article:15920021 | pubmed:abstractText | Phosphorylation and subsequent inactivation of glycogen synthase kinase (GSK)-3beta via the Akt/PI3-Kinase pathway during ischemic preconditioning (PC) has been shown to be cardioprotective. As FrzA/sFRP-1, a secreted antagonist of the Wnt/Frizzled pathway, is expressed in the heart and is able to decrease the phosphorylation of GSK-3beta in vitro on vascular cells, we examined its effect during PC using transgenic mouse overexpressing FrzA in cardiomyocytes (alpha-MHC promoter) under a conditional transgene expression approach (tet-off system). Overexpression of FrzA inhibited the increase in GSK-3beta phosphorylation as well as protein kinase C (PKC) epsilon activation in transgenic mice after PC as compared with littermates. Phospho-Akt (P-Akt), phospho-JNK, or the cytoplasmic beta-catenin levels were not modified, phospho-p38 (P-p38) was slightly increased in transgenic mice after PC as compared with littermates. FrzA transgenic mice displayed a larger infarct size and a greater worsening of cardiac function compared with littermates. All these differences were reversed by the addition of doxycycline. This study demonstrates for the first time that disruption of a beta-catenin independent Wnt/Frizzled pathway induces the activation of GSK-3beta and reverses the benefit of preconditioning. | lld:pubmed |
| pubmed-article:15920021 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15920021 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15920021 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15920021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15920021 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15920021 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15920021 | pubmed:issn | 1524-4571 | lld:pubmed |
| pubmed-article:15920021 | pubmed:author | pubmed-author:Dos... | lld:pubmed |
| pubmed-article:15920021 | pubmed:author | pubmed-author:DaretDanièleD | lld:pubmed |
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| pubmed-article:15920021 | pubmed:author | pubmed-author:DuplàaCécileC | lld:pubmed |
| pubmed-article:15920021 | pubmed:author | pubmed-author:CostetPierreP | lld:pubmed |
| pubmed-article:15920021 | pubmed:author | pubmed-author:BarandonLaure... | lld:pubmed |
| pubmed-article:15920021 | pubmed:author | pubmed-author:AllièresCécil... | lld:pubmed |
| pubmed-article:15920021 | pubmed:author | pubmed-author:Daniel... | lld:pubmed |
| pubmed-article:15920021 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15920021 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:15920021 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:15920021 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15920021 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15920021 | pubmed:pagination | 1299-306 | lld:pubmed |
| pubmed-article:15920021 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:15920021 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15920021 | pubmed:articleTitle | Involvement of FrzA/sFRP-1 and the Wnt/frizzled pathway in ischemic preconditioning. | lld:pubmed |
| pubmed-article:15920021 | pubmed:affiliation | Department of Cardiovascular Surgery, Hôpital Haut Lévêque, Pessac, France. | lld:pubmed |
| pubmed-article:15920021 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15920021 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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