| pubmed-article:1591777 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1591777 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1591777 | lifeskim:mentions | umls-concept:C0008546 | lld:lifeskim |
| pubmed-article:1591777 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1591777 | lifeskim:mentions | umls-concept:C1704332 | lld:lifeskim |
| pubmed-article:1591777 | lifeskim:mentions | umls-concept:C1516561 | lld:lifeskim |
| pubmed-article:1591777 | lifeskim:mentions | umls-concept:C0002270 | lld:lifeskim |
| pubmed-article:1591777 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1591777 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1591777 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:1591777 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1591777 | pubmed:dateCreated | 1992-6-26 | lld:pubmed |
| pubmed-article:1591777 | pubmed:abstractText | Current models suggest that tissue-specific genes are arranged in discrete, independently controlled segments of chromatin referred to as regulatory domains. Transition from a closed to open chromatin structure may be an important step in the regulation of gene expression. To determine whether the human alpha-globin cluster, like the beta-globin cluster, lies within a discrete, erythroid-specific domain, we have examined the long-range genomic organization and chromatin structure around this region. The alpha genes lie adjacent to at least four widely expressed genes. The major alpha-globin regulatory element lies 40 kb away from the cluster within an intron of one of these genes. Therefore, unlike the beta cluster, cis-acting sequences controlling alpha gene expression are dispersed within a region of chromatin that is open in both erythroid and nonerythroid cells. This implies a difference in the hierarchical control of alpha- and beta-globin expression. | lld:pubmed |
| pubmed-article:1591777 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1591777 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1591777 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1591777 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1591777 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1591777 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1591777 | pubmed:month | May | lld:pubmed |
| pubmed-article:1591777 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:1591777 | pubmed:author | pubmed-author:HiggsD RDR | lld:pubmed |
| pubmed-article:1591777 | pubmed:author | pubmed-author:SimmonsD LDL | lld:pubmed |
| pubmed-article:1591777 | pubmed:author | pubmed-author:VickersM AMA | lld:pubmed |
| pubmed-article:1591777 | pubmed:author | pubmed-author:VyasPP | lld:pubmed |
| pubmed-article:1591777 | pubmed:author | pubmed-author:AyyubHH | lld:pubmed |
| pubmed-article:1591777 | pubmed:author | pubmed-author:CraddockC FCF | lld:pubmed |
| pubmed-article:1591777 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1591777 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:1591777 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:1591777 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1591777 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1591777 | pubmed:pagination | 781-93 | lld:pubmed |
| pubmed-article:1591777 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
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| pubmed-article:1591777 | pubmed:meshHeading | pubmed-meshheading:1591777-... | lld:pubmed |
| pubmed-article:1591777 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1591777 | pubmed:articleTitle | Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin. | lld:pubmed |
| pubmed-article:1591777 | pubmed:affiliation | MRC Molecular Haematology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, England. | lld:pubmed |
| pubmed-article:1591777 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1591777 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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