| pubmed-article:15916606 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15916606 | lifeskim:mentions | umls-concept:C0004595 | lld:lifeskim |
| pubmed-article:15916606 | lifeskim:mentions | umls-concept:C0002521 | lld:lifeskim |
| pubmed-article:15916606 | lifeskim:mentions | umls-concept:C0029073 | lld:lifeskim |
| pubmed-article:15916606 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:15916606 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:15916606 | lifeskim:mentions | umls-concept:C0182953 | lld:lifeskim |
| pubmed-article:15916606 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:15916606 | lifeskim:mentions | umls-concept:C2348867 | lld:lifeskim |
| pubmed-article:15916606 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15916606 | pubmed:dateCreated | 2005-5-26 | lld:pubmed |
| pubmed-article:15916606 | pubmed:abstractText | The Bacillus subtilis ilv-leu operon involved in the biosynthesis of branched-chain amino acids is under negative regulation mediated by TnrA and CodY, which recognize and bind to their respective cis-elements located upstream of the ilv-leu promoter. This operon is known to be under CcpA-dependent positive regulation. We have currently identified a catabolite-responsive element (cre) for this positive regulation (bases -96 to -82; +1 is the ilv-leu transcription initiation base) by means of DNase I-footprinting in vitro, and deletion and base-substitution analyses of cre. Under nitrogen-rich growth conditions in glucose-minimal medium supplemented with glutamine and amino acids, CcpA and CodY exerted positive and negative regulation of ilv-leu, respectively, but TnrA did not function. Moreover, CcpA and CodY were able to function without their counteracting regulation of each other, although the CcpA-dependent positive regulation did not overcome the CodY-dependent negative regulation. Furthermore, under nitrogen-limited conditions in glucose-minimal medium with glutamate as the sole nitrogen source, CcpA and TnrA exerted positive and negative regulation, respectively, but CodY did not function. This CcpA-dependent positive regulation occurred without the TnrA-dependent negative regulation. However, the TnrA-dependent negative regulation did not occur without the CcpA-dependent positive regulation, raising the possibility that this negative regulation might decrease the CcpA-dependent positive regulation. The physiological role of this elaborate transcription regulation of the B. subtilis ilv-leu operon in overall metabolic regulation in this organism is discussed. | lld:pubmed |
| pubmed-article:15916606 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15916606 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15916606 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15916606 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15916606 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15916606 | pubmed:issn | 0950-382X | lld:pubmed |
| pubmed-article:15916606 | pubmed:author | pubmed-author:FujitaYasutar... | lld:pubmed |
| pubmed-article:15916606 | pubmed:author | pubmed-author:SatomuraTaken... | lld:pubmed |
| pubmed-article:15916606 | pubmed:author | pubmed-author:DeutscherJose... | lld:pubmed |
| pubmed-article:15916606 | pubmed:author | pubmed-author:HirookaKazuta... | lld:pubmed |
| pubmed-article:15916606 | pubmed:author | pubmed-author:TojoShigeoS | lld:pubmed |
| pubmed-article:15916606 | pubmed:author | pubmed-author:MorisakiKaori... | lld:pubmed |
| pubmed-article:15916606 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15916606 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:15916606 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15916606 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15916606 | pubmed:pagination | 1560-73 | lld:pubmed |
| pubmed-article:15916606 | pubmed:dateRevised | 2009-7-17 | lld:pubmed |
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| pubmed-article:15916606 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15916606 | pubmed:articleTitle | Elaborate transcription regulation of the Bacillus subtilis ilv-leu operon involved in the biosynthesis of branched-chain amino acids through global regulators of CcpA, CodY and TnrA. | lld:pubmed |
| pubmed-article:15916606 | pubmed:affiliation | Department of Biotechnology, Faculty of Life Science and Biotechnology, Fukuyama University, 985 Sanzo, Higashimura-cho, Fukuyama-shi, Hiroshima 729-0292, Japan. | lld:pubmed |
| pubmed-article:15916606 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15916606 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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