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pubmed-article:15914907pubmed:dateCreated2005-5-25lld:pubmed
pubmed-article:15914907pubmed:abstractTextDioxins induce adverse effects through transformation of the cytosolic aryl hydrocarbon receptor (AhR). Our previous study found that flavones and flavonols at dietary levels suppress AhR transformation. In the present study, we investigated whether 20 anthocyans dissolved in trifluoroacetic acid (TFA)-MeOH suppressed AhR transformation in a cell-free system and in Hepa-1c1c7 cells. Although four compounds at 50 muM suppressed 0.1 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR transformation and their effects were dose-dependent in the cell-free system, they were ineffective at 0.5 muM, which is close to physiological concentration. Moreover, no anthocyan at 50 muM tested here suppressed 0.1 nM TCDD-induced AhR transformation in Hepa-1c1c7 cells. We also confirmed that protocatechuic acid and related compounds, which are possible metabolites of anthocyans, did not affect the transformation in the cell-free system. It is concluded that anthocyans are not suitable candidates for protection from dioxin toxicity.lld:pubmed
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pubmed-article:15914907pubmed:monthMaylld:pubmed
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pubmed-article:15914907pubmed:authorpubmed-author:AshidaHitoshi...lld:pubmed
pubmed-article:15914907pubmed:authorpubmed-author:FukudaItsukoIlld:pubmed
pubmed-article:15914907pubmed:authorpubmed-author:KanekoAtsushi...lld:pubmed
pubmed-article:15914907pubmed:authorpubmed-author:HosokawaKeizo...lld:pubmed
pubmed-article:15914907pubmed:authorpubmed-author:NishiumiShinSlld:pubmed
pubmed-article:15914907pubmed:authorpubmed-author:MukaiRieRlld:pubmed
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pubmed-article:15914907pubmed:volume69lld:pubmed
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pubmed-article:15914907pubmed:pagination896-903lld:pubmed
pubmed-article:15914907pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15914907pubmed:year2005lld:pubmed
pubmed-article:15914907pubmed:articleTitleAnthocyans fail to suppress transformation of aryl hydrocarbon receptor induced by dioxin.lld:pubmed
pubmed-article:15914907pubmed:affiliationDepartment of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Hyogo, Japan.lld:pubmed
pubmed-article:15914907pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15914907pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed