| pubmed-article:15913602 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15913602 | lifeskim:mentions | umls-concept:C0040822 | lld:lifeskim |
| pubmed-article:15913602 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:15913602 | lifeskim:mentions | umls-concept:C1708300 | lld:lifeskim |
| pubmed-article:15913602 | lifeskim:mentions | umls-concept:C0051318 | lld:lifeskim |
| pubmed-article:15913602 | lifeskim:mentions | umls-concept:C0064219 | lld:lifeskim |
| pubmed-article:15913602 | lifeskim:mentions | umls-concept:C1172779 | lld:lifeskim |
| pubmed-article:15913602 | lifeskim:mentions | umls-concept:C1415809 | lld:lifeskim |
| pubmed-article:15913602 | lifeskim:mentions | umls-concept:C0205381 | lld:lifeskim |
| pubmed-article:15913602 | lifeskim:mentions | umls-concept:C1705810 | lld:lifeskim |
| pubmed-article:15913602 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15913602 | pubmed:dateCreated | 2005-6-6 | lld:pubmed |
| pubmed-article:15913602 | pubmed:abstractText | These experiments sought to determine the influence of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and the endocannabinoid system in the functional expression of the serotonin (5-HT) type 2A receptor-mediated wet dog shake response. Male Long-Evans rats were pretreated with either 1 mg/kg i.p. of the 5-HT(2A/2C) receptor antagonist ketanserin; 1, 10 or 30 mg/kg i.p. of the AMPA/kainate antagonist 6,7-dinitroquinnoxaline-2,3-dione (DNQX); 1, 5 or 10 mg/kg i.p. of the endocannabinoid uptake inhibitor AM404; or 1, 5 or 10 mg/kg i.p. of the cannabinoid CB(1) receptor antagonist AM 251 prior to injection of the 5-HT(2A/2C) receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI, 1 mg/kg i.p.). Results demonstrated that 10 mg/kg of AM404 significantly reduced the expression of DOI-induced wet dog shakes, but lower doses were ineffective. Administration of AM251 did not induce wet dog shakes behavior when administered alone, but significantly potentiated DOI-induced wet dog shaking behavior at a dose of 10 mg/kg. Pretreatment with DNQX significantly reduced the expression of DOI-induced wet dog shakes at all doses tested. These data suggest that AMPA/kainate receptors play a role in the mediation of 5-HT(2A) receptor activity, whereas the endocannabinoid system may act as a regulatory buffer system during periods of elevated activity, but not under basal conditions. | lld:pubmed |
| pubmed-article:15913602 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15913602 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15913602 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15913602 | pubmed:month | May | lld:pubmed |
| pubmed-article:15913602 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:15913602 | pubmed:author | pubmed-author:GorzalkaBoris... | lld:pubmed |
| pubmed-article:15913602 | pubmed:author | pubmed-author:HillMatthew... | lld:pubmed |
| pubmed-article:15913602 | pubmed:author | pubmed-author:SunJane CJC | lld:pubmed |
| pubmed-article:15913602 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15913602 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:15913602 | pubmed:volume | 516 | lld:pubmed |
| pubmed-article:15913602 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15913602 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15913602 | pubmed:pagination | 28-33 | lld:pubmed |
| pubmed-article:15913602 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15913602 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15913602 | pubmed:articleTitle | Functional role of the endocannabinoid system and AMPA/kainate receptors in 5-HT2A receptor-mediated wet dog shakes. | lld:pubmed |
| pubmed-article:15913602 | pubmed:affiliation | Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B.C., Canada V6T 1Z4. bgorzalka@psych.ubc.ca | lld:pubmed |
| pubmed-article:15913602 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15913602 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15913602 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15913602 | lld:pubmed |
