| pubmed-article:15911309 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15911309 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:15911309 | lifeskim:mentions | umls-concept:C0268563 | lld:lifeskim |
| pubmed-article:15911309 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:15911309 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:15911309 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:15911309 | lifeskim:mentions | umls-concept:C2267054 | lld:lifeskim |
| pubmed-article:15911309 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:15911309 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:15911309 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:15911309 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
| pubmed-article:15911309 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15911309 | pubmed:dateCreated | 2005-5-24 | lld:pubmed |
| pubmed-article:15911309 | pubmed:abstractText | Compound 7 was identified as the active metabolite of 6 by HPLC and mass spectral analysis. Modification of lead compound 7 by transformation of its N-oxide 6-6 biaryl ring system and fused aromatics produced a series of non-basic fXa inhibitors with excellent potency in anti-fXa and anticoagulant assays. The optimized compounds 73b and 75b showed sub to one digit micromolar anticoagulant activity (PTCT2). Particularly, anti-fXa activity was detected in plasma of rats orally administered with 1mg/kg of compound 75b. | lld:pubmed |
| pubmed-article:15911309 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15911309 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15911309 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15911309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15911309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15911309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15911309 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15911309 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15911309 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:SuzukiMakotoM | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:SuzukiMasanor... | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:YoshinoToshih... | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:KomoriyaSatos... | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:NagaharaTakay... | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:HaginoyaNoriy... | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:KobayashiShoz... | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:NagataTsutomu... | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:MochizukiAkiy... | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:HorinoHaruhik... | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:IsobeYumikoY | lld:pubmed |
| pubmed-article:15911309 | pubmed:author | pubmed-author:FurugooriTake... | lld:pubmed |
| pubmed-article:15911309 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15911309 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:15911309 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:15911309 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15911309 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15911309 | pubmed:pagination | 3927-54 | lld:pubmed |
| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
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| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
| pubmed-article:15911309 | pubmed:meshHeading | pubmed-meshheading:15911309... | lld:pubmed |
| pubmed-article:15911309 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15911309 | pubmed:articleTitle | Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites. | lld:pubmed |
| pubmed-article:15911309 | pubmed:affiliation | Tokyo R&D Center, Daiichi Pharmaceutical Co. Ltd, 16-13 Kita-Kasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan. komor0ni@daiichipharm.co.jp | lld:pubmed |
| pubmed-article:15911309 | pubmed:publicationType | Journal Article | lld:pubmed |
