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pubmed-article:1590984pubmed:abstractTextThe expression of the class-II antigens of the major histocompatibility complex is tissue-specific, developmentally regulated in cells of the B lineage, and inducible by cytokine. Some of the molecular mechanisms that account for this regulation have recently been elucidated. DNA sequences upstream of human and mouse class-II genes that are critical for the transcription of these genes have been identified through transfection studies and transgenic analysis. Furthermore, a number of transcription factors that bind to important promoter motifs have recently been isolated. Examination of the class-II promoter in vivo both in the normal state and in patients with bare lymphocyte syndrome has further increased our understanding of class-II regulation.lld:pubmed
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pubmed-article:1590984pubmed:authorpubmed-author:GlimcherL HLHlld:pubmed
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pubmed-article:1590984pubmed:articleTitleSequences and factors: a guide to MHC class-II transcription.lld:pubmed
pubmed-article:1590984pubmed:affiliationDepartment of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115.lld:pubmed
pubmed-article:1590984pubmed:publicationTypeJournal Articlelld:pubmed
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