| pubmed-article:15908206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15908206 | lifeskim:mentions | umls-concept:C0226896 | lld:lifeskim |
| pubmed-article:15908206 | lifeskim:mentions | umls-concept:C0205531 | lld:lifeskim |
| pubmed-article:15908206 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:15908206 | lifeskim:mentions | umls-concept:C1527415 | lld:lifeskim |
| pubmed-article:15908206 | lifeskim:mentions | umls-concept:C0031453 | lld:lifeskim |
| pubmed-article:15908206 | lifeskim:mentions | umls-concept:C1827106 | lld:lifeskim |
| pubmed-article:15908206 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:15908206 | lifeskim:mentions | umls-concept:C2917254 | lld:lifeskim |
| pubmed-article:15908206 | lifeskim:mentions | umls-concept:C0935763 | lld:lifeskim |
| pubmed-article:15908206 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:15908206 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15908206 | pubmed:dateCreated | 2005-5-31 | lld:pubmed |
| pubmed-article:15908206 | pubmed:abstractText | anti-Substituted biaryl beta-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors that suffer from suboptimal selectivity and pharmacokinetics. This letter describes the substitution of the beta-methyl substituent with beta-polar substituents, culminating in the discovery of a beta-dimethylamide substituted phenylalanine derivative with an excellent potency, selectivity, and pharmacokinetic profile. | lld:pubmed |
| pubmed-article:15908206 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15908206 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15908206 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15908206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15908206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15908206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15908206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15908206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15908206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15908206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15908206 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15908206 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15908206 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:AliT ZTZ | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:LyonsKathryn... | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:WeberAnn EAE | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:ThornberryNan... | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:DuffyJoseph... | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:LeitingBarbar... | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:WuJoseph KJK | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:PatelReshma... | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:EdmondsonScot... | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:MastracchioAn... | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:HeHuaibingH | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:PetrovAleksan... | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:EiermannGeorg... | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:LeoneJoseph... | lld:pubmed |
| pubmed-article:15908206 | pubmed:author | pubmed-author:MakarewiczAma... | lld:pubmed |
| pubmed-article:15908206 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15908206 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15908206 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:15908206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15908206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15908206 | pubmed:pagination | 3048-52 | lld:pubmed |
| pubmed-article:15908206 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:meshHeading | pubmed-meshheading:15908206... | lld:pubmed |
| pubmed-article:15908206 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15908206 | pubmed:articleTitle | Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors. | lld:pubmed |
| pubmed-article:15908206 | pubmed:affiliation | Department of Medicinal Chemistry, Merck & Co. Inc., PO Box 2000, Rahway, NJ 07065, USA. scott_edmondson@merck.com | lld:pubmed |
| pubmed-article:15908206 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:15908206 | lld:chembl |
