Linked Life Data

15907367

Source:http://linkedlifedata.com/resource/pubmed/id/15907367

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pubmed-article:15907367pubmed:abstractTextWe investigated EBV viremia in matched serum and peripheral blood mononuclear cells (PBMCs) from one of the largest Italian cohort of Undifferentiated Carcinoma of Nasopharyngeal Type (UCNT) patients (N=34). By using a LMP-1 real-time PCR assay, we found that EBV DNA detection rate was 74% (median 8417 copies/ml) and 24% (median 164 copies/10(6)cells) on serum and PBMCs, respectively. Significantly higher serum EBV DNA levels were detected in patients with advanced UCNT (nodal stage N2 versus N0-1 and N3 versus N0-1, P=0.03 and 0.018; overall stage IV versus I-II, P=0.03). During the follow-up, there was also a statistically significant difference of EBV DNA viral load between patients with and without clinical relapse (P=0.008). We concluded that serum EBV DNA reflects the biological activity of the UCNT and may be a prognostic factor also in a low-incidence region.lld:pubmed
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pubmed-article:15907367pubmed:articleTitleClinical value of Epstein-Barr virus DNA levels in peripheral blood samples of Italian patients with undifferentiated carcinoma of nasopharyngeal type.lld:pubmed
pubmed-article:15907367pubmed:affiliationMicrobiology, Immunology and Virology Unit, Centro di Riferimento Oncologico, IRCCS, Via Pedemontana Occidentale, 12, Aviano (PN) 33081, Italy. micro@cro.itlld:pubmed
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