| pubmed-article:15905562 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15905562 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:15905562 | lifeskim:mentions | umls-concept:C0475463 | lld:lifeskim |
| pubmed-article:15905562 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:15905562 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:15905562 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:15905562 | lifeskim:mentions | umls-concept:C0442335 | lld:lifeskim |
| pubmed-article:15905562 | lifeskim:mentions | umls-concept:C0062675 | lld:lifeskim |
| pubmed-article:15905562 | lifeskim:mentions | umls-concept:C1627932 | lld:lifeskim |
| pubmed-article:15905562 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15905562 | pubmed:dateCreated | 2005-5-20 | lld:pubmed |
| pubmed-article:15905562 | pubmed:abstractText | The utility of recombinant adenovirus serotype 5 (rAd5) vector-based vaccines for HIV-1 and other pathogens will likely be limited by the high prevalence of pre-existing Ad5-specific neutralizing Abs (NAbs) in human populations. However, the immunodominant targets of Ad5-specific NAbs in humans remain poorly characterized. In this study, we assess the titers and primary determinants of Ad5-specific NAbs in individuals from both the United States and the developing world. Importantly, median Ad5-specific NAb titers were >10-fold higher in sub-Saharan Africa compared with the United States. Moreover, hexon-specific NAb titers were 4- to 10-fold higher than fiber-specific NAb titers in these cohorts by virus neutralization assays using capsid chimeric viruses. We next performed adoptive transfer studies in mice to evaluate the functional capacity of hexon- and fiber-specific NAbs to suppress the immunogenicity of a prototype rAd5-Env vaccine. Hexon-specific NAbs were remarkably efficient at suppressing Env-specific immune responses elicited by the rAd5 vaccine. In contrast, fiber-specific NAbs exerted only minimal suppressive effects on rAd5 vaccine immunogenicity. These data demonstrate that functionally significant Ad5-specific NAbs are directed primarily against the Ad5 hexon protein in both humans and mice. These studies suggest a potential strategy for engineering novel Ad5 vectors to evade dominant Ad5-specific NAbs. | lld:pubmed |
| pubmed-article:15905562 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15905562 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15905562 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15905562 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15905562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15905562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15905562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15905562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15905562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15905562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15905562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15905562 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15905562 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15905562 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:BarouchDan... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:LiftonMichell... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:GorgoneDarci... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:JacksonShawn... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:PeyerlFred... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:WalkerBruce... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:GoudsmitJaapJ | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:AddoMarylyn... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:VogelsRonaldR | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:SumidaShawn... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:HavengaMenzo... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:LockmanShahin... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:PeterTrevorT | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:TruittDiana... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:KishkoMichael... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:EssexMyronM | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:CustersJerome... | lld:pubmed |
| pubmed-article:15905562 | pubmed:author | pubmed-author:LemckertAngel... | lld:pubmed |
| pubmed-article:15905562 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15905562 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15905562 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:15905562 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15905562 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15905562 | pubmed:pagination | 7179-85 | lld:pubmed |
| pubmed-article:15905562 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15905562 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15905562 | pubmed:articleTitle | Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein. | lld:pubmed |
| pubmed-article:15905562 | pubmed:affiliation | Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. | lld:pubmed |
| pubmed-article:15905562 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15905562 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15905562 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15905562 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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