| pubmed-article:15902306 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15902306 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:15902306 | lifeskim:mentions | umls-concept:C0972232 | lld:lifeskim |
| pubmed-article:15902306 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:15902306 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15902306 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15902306 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15902306 | pubmed:dateCreated | 2005-6-2 | lld:pubmed |
| pubmed-article:15902306 | pubmed:abstractText | Diabetes mellitus is a major health concern, affecting more than 5% of the population. Here we describe a potential novel therapeutic agent for this disease, FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes. FGF-21-transgenic mice were viable and resistant to diet-induced obesity. Therapeutic administration of FGF-21 reduced plasma glucose and triglycerides to near normal levels in both ob/ob and db/db mice. These effects persisted for at least 24 hours following the cessation of FGF-21 administration. Importantly, FGF-21 did not induce mitogenicity, hypoglycemia, or weight gain at any dose tested in diabetic or healthy animals or when overexpressed in transgenic mice. Thus, we conclude that FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes. | lld:pubmed |
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| pubmed-article:15902306 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15902306 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15902306 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15902306 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15902306 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15902306 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:Kharitonenkov... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:BrozinickJose... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:HammondLisa... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:GromadaJesper... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:SanduskyGeorg... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:ShanafeltArme... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:MehrbodFarrok... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:KoesterAnjaA | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:GalbreathEliz... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:MicanovicRadm... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:WroblewskiVic... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:MoyersJulie... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:OwensRebecca... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:HawkinsEric... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:ShiyanovaTati... | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:FordAmy MAM | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:LiDe-ShanDS | lld:pubmed |
| pubmed-article:15902306 | pubmed:author | pubmed-author:JaskunasS... | lld:pubmed |
| pubmed-article:15902306 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15902306 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:15902306 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15902306 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15902306 | pubmed:pagination | 1627-35 | lld:pubmed |
| pubmed-article:15902306 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:meshHeading | pubmed-meshheading:15902306... | lld:pubmed |
| pubmed-article:15902306 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15902306 | pubmed:articleTitle | FGF-21 as a novel metabolic regulator. | lld:pubmed |
