| pubmed-article:15900595 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15900595 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:15900595 | lifeskim:mentions | umls-concept:C0007131 | lld:lifeskim |
| pubmed-article:15900595 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:15900595 | lifeskim:mentions | umls-concept:C0032790 | lld:lifeskim |
| pubmed-article:15900595 | lifeskim:mentions | umls-concept:C0085533 | lld:lifeskim |
| pubmed-article:15900595 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15900595 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15900595 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15900595 | pubmed:dateCreated | 2005-9-21 | lld:pubmed |
| pubmed-article:15900595 | pubmed:abstractText | Cisplatin-based (CDDP-based) adjuvant chemotherapy of non-small cell lung cancer (NSCLC) was reported to yield 5-15% improvement in 5-year survival compared to complete resection alone. The importance of information concerning preselection of good responders has become increasingly evident. The purpose of our study is the establishment of a preselection of good responders for CDDP-based adjuvant chemotherapy. We investigated protein expressions comparing intensity between parent strains (H69 and PC14 lung cancer cultured cells) and resistant strains against CDDP using 2-dimensional polyacrylamide gel electrophoresis (2-DE). Immunohistochemically, we evaluated the relationship between protein expression associated with CDDP-resistance and the clinical effects of platinum-based postoperative adjuvant chemotherapy using 126 surgically-resected NCLC materials. We detected 2 kinds of polypeptides that changed expression levels on 2-DE gels. The analyses of the amino acid sequence showed that these polypeptides were reticulocalbin (RCN) and glutathione-S-transferase-pi (GST-pi). The 2-DE analysis showed decreased expression in RCN and overexpression in GST-pi with the acquisition of CDDP-drug resistance. RCN-transfectant of H69 CDDP-resistant strain showed intermediate sensitivity between the parent strain and the CDDP-resistant strain. RCN-positive cases showed a statistically significant better disease-free survival only in the cases receiving postoperative platinum-based adjuvant chemotherapy after curative resection (p = 0.007). In addition, cases that were both RCN-positive and GST-pi-negative showed a statistically significantly better outcome (p = 0.0150). In the cases without postoperative adjuvant chemotherapy no relationship between the outcome and these expressions was seen. The evaluation of RCN and GST-pi might provide valuable information concerning postoperatively therapeutic strategy from the standpoint of individualized postoperative therapy. | lld:pubmed |
| pubmed-article:15900595 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15900595 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15900595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15900595 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15900595 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15900595 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:HiranoTakashi... | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:IkedaNorihiko... | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:KatoHarubumiH | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:MaedaMasahiro... | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:TsuboiMasahir... | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:KatoYasufumiY | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:MaedaJunichiJ | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:OhiraTatsuoT | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:AkimotoShingo... | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:NakamuraMihoM | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:GongYunboY | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:YashimaKoichi... | lld:pubmed |
| pubmed-article:15900595 | pubmed:author | pubmed-author:ShouYanningY | lld:pubmed |
| pubmed-article:15900595 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15900595 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:15900595 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:15900595 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15900595 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15900595 | pubmed:pagination | 460-8 | lld:pubmed |
| pubmed-article:15900595 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
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| pubmed-article:15900595 | pubmed:meshHeading | pubmed-meshheading:15900595... | lld:pubmed |
| pubmed-article:15900595 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15900595 | pubmed:articleTitle | Identification of postoperative adjuvant chemotherapy responders in non-small cell lung cancer by novel biomarker. | lld:pubmed |
| pubmed-article:15900595 | pubmed:affiliation | Department of Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan. thirano@tokyo-med.ac.jp | lld:pubmed |
| pubmed-article:15900595 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15900595 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2950 | entrezgene:pubmed | pubmed-article:15900595 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15900595 | lld:pubmed |
