| pubmed-article:15899801 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:15899801 | lifeskim:mentions | umls-concept:C1880274 | lld:lifeskim |
| pubmed-article:15899801 | lifeskim:mentions | umls-concept:C0293442 | lld:lifeskim |
| pubmed-article:15899801 | lifeskim:mentions | umls-concept:C0168424 | lld:lifeskim |
| pubmed-article:15899801 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:15899801 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:15899801 | lifeskim:mentions | umls-concept:C0887839 | lld:lifeskim |
| pubmed-article:15899801 | lifeskim:mentions | umls-concept:C1553877 | lld:lifeskim |
| pubmed-article:15899801 | lifeskim:mentions | umls-concept:C1608885 | lld:lifeskim |
| pubmed-article:15899801 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:15899801 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:15899801 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:15899801 | pubmed:dateCreated | 2005-5-18 | lld:pubmed |
| pubmed-article:15899801 | pubmed:abstractText | Although phosphatase and tensin homologue deleted on chromosome 10 (PTEN) localization in the nucleus and cytoplasm is established, the mechanism is unknown. PTEN is a tumor suppressor phosphatase that causes cell cycle arrest and/or apoptosis. Nuclear-cytoplasmic compartmentalization may be a novel mechanism in regulating these events. PTEN does not contain a traditional nuclear localization sequence (NLS); however, we identified putative NLS-like sequences, which we analyzed by site-directed mutagenesis and localization studies in MCF-7 cells. Two double site mutations exhibited nuclear localization defects. Furthermore, unlike wild-type PTEN, double NLS mutant PTEN did not interact with major vault protein (MVP), a previously hypothesized nuclear-cytoplasmic transport protein. We conclude that these two NLS-like sequences are required for PTEN nuclear import that is mediated by MVP. Further, we show that this MVP-mediated nuclear import is independent of PTEN phosphorylation and of the lipid and protein phosphatase activities of PTEN. | lld:pubmed |
| pubmed-article:15899801 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15899801 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15899801 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15899801 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15899801 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15899801 | pubmed:month | May | lld:pubmed |
| pubmed-article:15899801 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:15899801 | pubmed:author | pubmed-author:EngCharisC | lld:pubmed |
| pubmed-article:15899801 | pubmed:author | pubmed-author:Ginn-PeaseMar... | lld:pubmed |
| pubmed-article:15899801 | pubmed:author | pubmed-author:ChungJi-HyunJ... | lld:pubmed |
| pubmed-article:15899801 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15899801 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15899801 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:15899801 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15899801 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15899801 | pubmed:pagination | 4108-16 | lld:pubmed |
| pubmed-article:15899801 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15899801 | pubmed:meshHeading | pubmed-meshheading:15899801... | lld:pubmed |
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| pubmed-article:15899801 | pubmed:meshHeading | pubmed-meshheading:15899801... | lld:pubmed |
| pubmed-article:15899801 | pubmed:meshHeading | pubmed-meshheading:15899801... | lld:pubmed |
| pubmed-article:15899801 | pubmed:meshHeading | pubmed-meshheading:15899801... | lld:pubmed |
| pubmed-article:15899801 | pubmed:meshHeading | pubmed-meshheading:15899801... | lld:pubmed |
| pubmed-article:15899801 | pubmed:meshHeading | pubmed-meshheading:15899801... | lld:pubmed |
| pubmed-article:15899801 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15899801 | pubmed:articleTitle | Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein. | lld:pubmed |
| pubmed-article:15899801 | pubmed:affiliation | Clinical Cancer Genetics Program, Human Cancer Genetics Program, Comprehensive Cancer Center, Columbus, Ohio 43210, USA. | lld:pubmed |
| pubmed-article:15899801 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15899801 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15899801 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15899801 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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