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pubmed-article:15897584pubmed:abstractTextFlavopiridol potently enhances the effect of irinotecan with cures in colorectal cancer xenografts, and is associated with modulation of several molecular targets, including p21, Differentiation-related gene 1 (Drg1), and p53. We initiated a phase I trial of the sequential combination of irinotecan followed by flavopiridol to determine the maximal tolerated dose of this combination therapy.lld:pubmed
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pubmed-article:15897584pubmed:articleTitleA phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol.lld:pubmed
pubmed-article:15897584pubmed:affiliationDepartment of Medicine, Division of Solid Tumor Oncology, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.lld:pubmed
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