| pubmed-article:15890010 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15890010 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15890010 | lifeskim:mentions | umls-concept:C0206116 | lld:lifeskim |
| pubmed-article:15890010 | lifeskim:mentions | umls-concept:C0235032 | lld:lifeskim |
| pubmed-article:15890010 | lifeskim:mentions | umls-concept:C0282151 | lld:lifeskim |
| pubmed-article:15890010 | pubmed:issue | 5-6 | lld:pubmed |
| pubmed-article:15890010 | pubmed:dateCreated | 2005-5-13 | lld:pubmed |
| pubmed-article:15890010 | pubmed:abstractText | The herbicide paraquat (PQ) has been implicated as a potential risk factor for the development of Parkinson's disease. In this study, PQ (0.5-1 microM) was shown to be selectively toxic to dopaminergic (DA) neurons through the activation of microglial NADPH oxidase and the generation of superoxide. Neuron-glia cultures exposed to PQ exhibited a decrease in DA uptake and a decline in the number of tyrosine hydroxylase-immunoreactive cells. The selectivity of PQ for DA neurons was confirmed when PQ failed to alter gamma-aminobutyric acid uptake in neuron-glia cultures. Microglia-depleted cultures exposed to 1 microM PQ failed to demonstrate a reduction in DA uptake, identifying microglia as the critical cell type mediating PQ neurotoxicity. Neuron-glia cultures treated with PQ failed to generate tumor necrosis factor-alpha and nitric oxide. However, microglia-enriched cultures exposed to PQ produced extracellular superoxide, supporting the notion that microglia are a source of PQ-derived oxidative stress. Neuron-glia cultures from NADPH oxidase-deficient (PHOX-/-) mice, which lack the functional catalytic subunit of NADPH oxidase and are unable to produce the respiratory burst, failed to show neurotoxicity in response to PQ, in contrast to PHOX+/+ mice. Here we report a novel mechanism of PQinduced oxidative stress, where at lower doses, the indirect insult generated from microglial NADPH oxidase is the essential factor mediating DA neurotoxicity. | lld:pubmed |
| pubmed-article:15890010 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15890010 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15890010 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15890010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15890010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15890010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15890010 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15890010 | pubmed:issn | 1523-0864 | lld:pubmed |
| pubmed-article:15890010 | pubmed:author | pubmed-author:ZhangWeiW | lld:pubmed |
| pubmed-article:15890010 | pubmed:author | pubmed-author:HongJau-Shyon... | lld:pubmed |
| pubmed-article:15890010 | pubmed:author | pubmed-author:VeronesiBelli... | lld:pubmed |
| pubmed-article:15890010 | pubmed:author | pubmed-author:WilsonBelinda... | lld:pubmed |
| pubmed-article:15890010 | pubmed:author | pubmed-author:QinLiyaL | lld:pubmed |
| pubmed-article:15890010 | pubmed:author | pubmed-author:BlockMichelle... | lld:pubmed |
| pubmed-article:15890010 | pubmed:author | pubmed-author:ZhangWan-QinW... | lld:pubmed |
| pubmed-article:15890010 | pubmed:author | pubmed-author:WuXue-FeiXF | lld:pubmed |
| pubmed-article:15890010 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15890010 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:15890010 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15890010 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15890010 | pubmed:pagination | 654-61 | lld:pubmed |
| pubmed-article:15890010 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:15890010 | pubmed:meshHeading | pubmed-meshheading:15890010... | lld:pubmed |
| pubmed-article:15890010 | pubmed:articleTitle | The role of microglia in paraquat-induced dopaminergic neurotoxicity. | lld:pubmed |
| pubmed-article:15890010 | pubmed:affiliation | Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. | lld:pubmed |
| pubmed-article:15890010 | pubmed:publicationType | Journal Article | lld:pubmed |
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