Linked Life Data

15878501

Source:http://linkedlifedata.com/resource/pubmed/id/15878501

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15878501rdf:typepubmed:Citationlld:pubmed
pubmed-article:15878501lifeskim:mentionsumls-concept:C0220781lld:lifeskim
pubmed-article:15878501lifeskim:mentionsumls-concept:C1883254lld:lifeskim
pubmed-article:15878501lifeskim:mentionsumls-concept:C1548779lld:lifeskim
pubmed-article:15878501lifeskim:mentionsumls-concept:C1947902lld:lifeskim
pubmed-article:15878501lifeskim:mentionsumls-concept:C2827499lld:lifeskim
pubmed-article:15878501lifeskim:mentionsumls-concept:C0205460lld:lifeskim
pubmed-article:15878501lifeskim:mentionsumls-concept:C0871161lld:lifeskim
pubmed-article:15878501lifeskim:mentionsumls-concept:C0536972lld:lifeskim
pubmed-article:15878501lifeskim:mentionsumls-concept:C0243072lld:lifeskim
pubmed-article:15878501lifeskim:mentionsumls-concept:C1167624lld:lifeskim
pubmed-article:15878501pubmed:issue4lld:pubmed
pubmed-article:15878501pubmed:dateCreated2005-5-9lld:pubmed
pubmed-article:15878501pubmed:abstractTextFour analogues of AG957, a known inhibitor of the tyrosine kinase p210(bcr-abl), have been synthesized and tested for their growth inhibitory effect against the BCR/ABL-positive FDrv210C cells as well as the epidermal growth factor (EGF) receptor-positive Baf/ERX cells. All compounds that can undergo oxidation to the corresponding quinone demonstrated inhibition of FDrv210C cells and Baf/ERX cells. Compounds that cannot become oxidized showed significantly less inhibition of BCR/ABL- or EGF receptor-mediated cell proliferation. The (11)C-labeled compounds were prepared by labeling 4-aminobenzoic acid using [(11)C]CH(3)I, which afforded the corresponding (11)C-labeled methyl ester in excellent yields. Subsequent condensation of the amino group with an appropriately substituted hydroxy benzaldehyde formed the respective Schiff base. Reduction of this compound with NaBH(3)CN gave the (11)C-labeled inhibitors in an overall radiochemical yield of 17.3+/-2.1% (n=3; not decay corrected) and an average specific radioactivity of 40 GBq/micromol (1.1 Ci/micromol) at the end of synthesis. The total synthesis time from EOB including HPLC purification and formulation was 45 min.lld:pubmed
pubmed-article:15878501pubmed:languageenglld:pubmed
pubmed-article:15878501pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15878501pubmed:citationSubsetIMlld:pubmed
pubmed-article:15878501pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15878501pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15878501pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15878501pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15878501pubmed:statusMEDLINElld:pubmed
pubmed-article:15878501pubmed:monthMaylld:pubmed
pubmed-article:15878501pubmed:issn0969-8051lld:pubmed
pubmed-article:15878501pubmed:authorpubmed-author:Tochon-Danguy...lld:pubmed
pubmed-article:15878501pubmed:authorpubmed-author:SachinidisJoh...lld:pubmed
pubmed-article:15878501pubmed:authorpubmed-author:ScottAndrew...lld:pubmed
pubmed-article:15878501pubmed:authorpubmed-author:NiceEdouard...lld:pubmed
pubmed-article:15878501pubmed:authorpubmed-author:NerrieMaureen...lld:pubmed
pubmed-article:15878501pubmed:authorpubmed-author:AckermannUweUlld:pubmed
pubmed-article:15878501pubmed:issnTypePrintlld:pubmed
pubmed-article:15878501pubmed:volume32lld:pubmed
pubmed-article:15878501pubmed:ownerNLMlld:pubmed
pubmed-article:15878501pubmed:authorsCompleteYlld:pubmed
pubmed-article:15878501pubmed:pagination323-8lld:pubmed
pubmed-article:15878501pubmed:dateRevised2007-11-15lld:pubmed
pubmed-article:15878501pubmed:meshHeadingpubmed-meshheading:15878501...lld:pubmed
pubmed-article:15878501pubmed:meshHeadingpubmed-meshheading:15878501...lld:pubmed
pubmed-article:15878501pubmed:meshHeadingpubmed-meshheading:15878501...lld:pubmed
pubmed-article:15878501pubmed:meshHeadingpubmed-meshheading:15878501...lld:pubmed
pubmed-article:15878501pubmed:meshHeadingpubmed-meshheading:15878501...lld:pubmed
pubmed-article:15878501pubmed:meshHeadingpubmed-meshheading:15878501...lld:pubmed
pubmed-article:15878501pubmed:meshHeadingpubmed-meshheading:15878501...lld:pubmed
pubmed-article:15878501pubmed:meshHeadingpubmed-meshheading:15878501...lld:pubmed
pubmed-article:15878501pubmed:meshHeadingpubmed-meshheading:15878501...lld:pubmed
pubmed-article:15878501pubmed:year2005lld:pubmed
pubmed-article:15878501pubmed:articleTitleSynthesis, 11C labeling and biological properties of derivatives of the tyrphostin AG957.lld:pubmed
pubmed-article:15878501pubmed:affiliationCentre for PET, Austin Health, Heidelberg, VIC 3084, Australia. ackerman@petnm.unimelb.edu.aulld:pubmed
pubmed-article:15878501pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15878501pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:15878501pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:15878501pubmed:publicationTypeEvaluation Studieslld:pubmed