| pubmed-article:1587423 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1587423 | lifeskim:mentions | umls-concept:C0030664 | lld:lifeskim |
| pubmed-article:1587423 | lifeskim:mentions | umls-concept:C0019904 | lld:lifeskim |
| pubmed-article:1587423 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:1587423 | lifeskim:mentions | umls-concept:C0018995 | lld:lifeskim |
| pubmed-article:1587423 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:1587423 | lifeskim:mentions | umls-concept:C1552617 | lld:lifeskim |
| pubmed-article:1587423 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:1587423 | lifeskim:mentions | umls-concept:C0282443 | lld:lifeskim |
| pubmed-article:1587423 | lifeskim:mentions | umls-concept:C0868928 | lld:lifeskim |
| pubmed-article:1587423 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1587423 | pubmed:dateCreated | 1992-6-19 | lld:pubmed |
| pubmed-article:1587423 | pubmed:abstractText | Liver pathology was assessed in 135 patients with well-defined genetic hemochromatosis ranging from mild disease to severe overload. Three lesions were clearly linked to iron-overload intensity--scarce sidero-necrosis, mild inflammation, and progressive fibrosis. Iron-free foci made of typical or dysplastic hepatocytes were found in 7.4% of the cases. An original grading allowed a reliable quantification of iron and the study of cellular and lobular distribution of iron, which permitted (a) the accurate identification of a decreasing iron gradient in hepatocytes from zone 1 to zone 3 in all cases, (b) the definition of a threshold hepatocytic/mesenchymal iron ratio related to the appearance of sidero-necrosis and to the development of fibrosis, and (c) demonstration that non-iron-related factors (mainly alcoholism) could shift iron from hepatocytes to sinusoidal cells without an increase in the total liver iron amount. This study provides a dynamic view of the iron overload process and suggests that sidero-necrosis and progressive sinusoidal iron overload play a role in the development of fibrosis in human genetic hemochromatosis. | lld:pubmed |
| pubmed-article:1587423 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1587423 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1587423 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1587423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1587423 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1587423 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1587423 | pubmed:issn | 0016-5085 | lld:pubmed |
| pubmed-article:1587423 | pubmed:author | pubmed-author:BrissotPP | lld:pubmed |
| pubmed-article:1587423 | pubmed:author | pubmed-author:MoirandRR | lld:pubmed |
| pubmed-article:1587423 | pubmed:author | pubmed-author:TurlinBB | lld:pubmed |
| pubmed-article:1587423 | pubmed:author | pubmed-author:GuyaderDD | lld:pubmed |
| pubmed-article:1587423 | pubmed:author | pubmed-author:JouanolleHH | lld:pubmed |
| pubmed-article:1587423 | pubmed:author | pubmed-author:JacquelinetCC | lld:pubmed |
| pubmed-article:1587423 | pubmed:author | pubmed-author:LoréalOO | lld:pubmed |
| pubmed-article:1587423 | pubmed:author | pubmed-author:DeugnierY MYM | lld:pubmed |
| pubmed-article:1587423 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1587423 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:1587423 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1587423 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1587423 | pubmed:pagination | 2050-9 | lld:pubmed |
| pubmed-article:1587423 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1587423 | pubmed:meshHeading | pubmed-meshheading:1587423-... | lld:pubmed |
| pubmed-article:1587423 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1587423 | pubmed:articleTitle | Liver pathology in genetic hemochromatosis: a review of 135 homozygous cases and their bioclinical correlations. | lld:pubmed |
| pubmed-article:1587423 | pubmed:affiliation | Clinique des Maladies du Foie, Inserm U49, Rennes, France. | lld:pubmed |
| pubmed-article:1587423 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1587423 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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