| pubmed-article:15872096 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15872096 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15872096 | lifeskim:mentions | umls-concept:C0034809 | lld:lifeskim |
| pubmed-article:15872096 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:15872096 | lifeskim:mentions | umls-concept:C2917435 | lld:lifeskim |
| pubmed-article:15872096 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:15872096 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:15872096 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:15872096 | pubmed:dateCreated | 2005-5-5 | lld:pubmed |
| pubmed-article:15872096 | pubmed:abstractText | Increasing data suggest that impairments of cellular plasticity/resilience underlie the pathophysiology of bipolar disorder. A series of microarray studies with validating criteria have recently revealed a common, novel target for the long-term actions of the structurally highly dissimilar mood stabilizers lithium and valproate: BAG-1 [BCL-2 (B-cell CLL/lymphoma 2)-associated athanogene]. Because BAG-1 attenuates glucocorticoid receptor (GR) nuclear translocation, activates ERK (extracellular signal-regulated kinase) MAP (mitogen-activated protein) kinases, and potentiates anti-apoptotic functions of BCL-2, extensive additional studies were undertaken. Chronic administration of both agents at therapeutic doses increased the expression of BAG-1 in rat hippocampus. Furthermore, these findings were validated at the protein level, and the effects were seen in a time frame consistent with therapeutic effects and were specific for mood stabilizers. Functional studies showed that either lithium or valproate, at therapeutically relevant levels, inhibited dexamethasone-induced GR nuclear translocation and inhibited GR transcriptional activity. Furthermore, small interfering RNA studies showed that these inhibitory effects on GR activity were mediated, at least in part, through BAG-1. The observation that BAG-1 inhibits glucocorticoid activation suggests that mood stabilizers may counteract the deleterious effects of hypercortisolemia seen in bipolar disorder by upregulating BAG-1. Additionally, these studies suggest that regulation of GR-mediated plasticity may play a role in the treatment of bipolar disorder and raise the possibility that agents affecting BAG-1 more directly may represent novel therapies for this devastating illness. | lld:pubmed |
| pubmed-article:15872096 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15872096 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15872096 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15872096 | pubmed:month | May | lld:pubmed |
| pubmed-article:15872096 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:15872096 | pubmed:author | pubmed-author:HUNTP JPJ | lld:pubmed |
| pubmed-article:15872096 | pubmed:author | pubmed-author:ZhangLeiL | lld:pubmed |
| pubmed-article:15872096 | pubmed:author | pubmed-author:LiXiaoxiaX | lld:pubmed |
| pubmed-article:15872096 | pubmed:author | pubmed-author:ChenJingshanJ | lld:pubmed |
| pubmed-article:15872096 | pubmed:author | pubmed-author:ChenGuangG | lld:pubmed |
| pubmed-article:15872096 | pubmed:author | pubmed-author:ManjiHusseini... | lld:pubmed |
| pubmed-article:15872096 | pubmed:author | pubmed-author:GrayNeil ANA | lld:pubmed |
| pubmed-article:15872096 | pubmed:author | pubmed-author:ZhouRulunR | lld:pubmed |
| pubmed-article:15872096 | pubmed:author | pubmed-author:YuanPeixiongP | lld:pubmed |
| pubmed-article:15872096 | pubmed:author | pubmed-author:Damschroder-W... | lld:pubmed |
| pubmed-article:15872096 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15872096 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:15872096 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:15872096 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15872096 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15872096 | pubmed:pagination | 4493-502 | lld:pubmed |
| pubmed-article:15872096 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15872096 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15872096 | pubmed:articleTitle | The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers. | lld:pubmed |
| pubmed-article:15872096 | pubmed:affiliation | Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland 20852, USA. | lld:pubmed |
| pubmed-article:15872096 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15872096 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15872096 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15872096 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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