| pubmed-article:15868913 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15868913 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:15868913 | lifeskim:mentions | umls-concept:C0543467 | lld:lifeskim |
| pubmed-article:15868913 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:15868913 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:15868913 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:15868913 | lifeskim:mentions | umls-concept:C0077906 | lld:lifeskim |
| pubmed-article:15868913 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:15868913 | pubmed:issue | 2A | lld:pubmed |
| pubmed-article:15868913 | pubmed:dateCreated | 2005-5-4 | lld:pubmed |
| pubmed-article:15868913 | pubmed:abstractText | Recently, we have reported that surgical stress promoted the metastasis of murine colon carcinoma cells to the lung by inducing the expression of proteases such as matrix metalloprotease-9 (MMP-9) in lung tissue. Urinary trypsin inhibitor (UTI) is a serine protease inhibitor frequently used to treat pancreatitis and to improve the microcirculatory environment. The purpose of this study was to investigate the anti-metastatic properties of UTI in an animal model of surgical stress-induced cancer metastasis. The intraperitoneal administration of UTI after the intravenous injection of colon 26-L5 carcinoma (colon 26-L5) cells into mice subjected to surgical stress suppressed the enhancement of lung metastasis (p<0.05). Furthermore, we investigated the effect of UTI on tumor growth, adhesion to fibronectin, migration, invasion and enzymatic degradation in colon 26-L5. UTI reduced the invasive ability and the degradation by MMP-9 of gelatin substrate in colon 26-L5 cells. UTI may improve therapeutic efficacy in cancer patients after major surgery. | lld:pubmed |
| pubmed-article:15868913 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15868913 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15868913 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15868913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15868913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15868913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15868913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15868913 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15868913 | pubmed:issn | 0250-7005 | lld:pubmed |
| pubmed-article:15868913 | pubmed:author | pubmed-author:SakuraiHiroak... | lld:pubmed |
| pubmed-article:15868913 | pubmed:author | pubmed-author:TsuchiyaYasun... | lld:pubmed |
| pubmed-article:15868913 | pubmed:author | pubmed-author:TsukadaKazuhi... | lld:pubmed |
| pubmed-article:15868913 | pubmed:author | pubmed-author:SaikiIkuoI | lld:pubmed |
| pubmed-article:15868913 | pubmed:author | pubmed-author:YoshiokaIsaku... | lld:pubmed |
| pubmed-article:15868913 | pubmed:author | pubmed-author:KoizumiKeiich... | lld:pubmed |
| pubmed-article:15868913 | pubmed:author | pubmed-author:OnishiYasuhar... | lld:pubmed |
| pubmed-article:15868913 | pubmed:author | pubmed-author:AozukaYasushi... | lld:pubmed |
| pubmed-article:15868913 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15868913 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:15868913 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15868913 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15868913 | pubmed:pagination | 815-20 | lld:pubmed |
| pubmed-article:15868913 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:meshHeading | pubmed-meshheading:15868913... | lld:pubmed |
| pubmed-article:15868913 | pubmed:articleTitle | Urinary trypsin inhibitor suppresses surgical stress-facilitated lung metastasis of murine colon 26-L5 carcinoma cells. | lld:pubmed |
| pubmed-article:15868913 | pubmed:affiliation | Second Department of Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani Toyama 930-0194, Japan. | lld:pubmed |
| pubmed-article:15868913 | pubmed:publicationType | Journal Article | lld:pubmed |
