| pubmed-article:15867298 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15867298 | lifeskim:mentions | umls-concept:C0009319 | lld:lifeskim |
| pubmed-article:15867298 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:15867298 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15867298 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:15867298 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:15867298 | lifeskim:mentions | umls-concept:C0286762 | lld:lifeskim |
| pubmed-article:15867298 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15867298 | pubmed:dateCreated | 2005-5-3 | lld:pubmed |
| pubmed-article:15867298 | pubmed:abstractText | Milk kappa-casein-derived glycomacropeptide has immunomodulatory and bacterial toxin binding effects. The intestinal anti-inflammatory activity of glycomacropeptide was assessed in trinitrobenzenesulfonic acid-induced colitis in rats. Rats were administered glycomacropeptide daily starting either 2 d before (pretreatment) or 3 h after (post-treatment) colitis induction. Pretreatment with glycomacropeptide had a dose-dependent anti-inflammatory effect, characterized by lower body weight loss, decreased anorexia (57%), colonic damage (65%), and weight to length ratio (32%), as well as a reduction in colonic alkaline phosphatase activity (42%) and interleukin 1, trefoil factor 3, and inducible nitric oxide synthase mRNA levels (P < 0.05). The mechanism of action of glycomacropeptide is unknown but is consistent with an inhibition of the activation of immune cells. The magnitude of the anti-inflammatory effect was generally comparable to that of sulfasalazine, an established drug used in the treatment of inflammatory bowel disease. Bovine glycomacropeptide may play a role in the management of patients with inflammatory bowel disease. | lld:pubmed |
| pubmed-article:15867298 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15867298 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15867298 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15867298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15867298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15867298 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15867298 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15867298 | pubmed:month | May | lld:pubmed |
| pubmed-article:15867298 | pubmed:issn | 0022-3166 | lld:pubmed |
| pubmed-article:15867298 | pubmed:author | pubmed-author:ZarzueloAnton... | lld:pubmed |
| pubmed-article:15867298 | pubmed:author | pubmed-author:Martínez-Augu... | lld:pubmed |
| pubmed-article:15867298 | pubmed:author | pubmed-author:Sánchez de... | lld:pubmed |
| pubmed-article:15867298 | pubmed:author | pubmed-author:DaddaouaAbdel... | lld:pubmed |
| pubmed-article:15867298 | pubmed:author | pubmed-author:PuertaVíctorV | lld:pubmed |
| pubmed-article:15867298 | pubmed:author | pubmed-author:SuárezMaría... | lld:pubmed |
| pubmed-article:15867298 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15867298 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:15867298 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15867298 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15867298 | pubmed:pagination | 1164-70 | lld:pubmed |
| pubmed-article:15867298 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15867298 | pubmed:meshHeading | pubmed-meshheading:15867298... | lld:pubmed |
| pubmed-article:15867298 | pubmed:meshHeading | pubmed-meshheading:15867298... | lld:pubmed |
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| pubmed-article:15867298 | pubmed:meshHeading | pubmed-meshheading:15867298... | lld:pubmed |
| pubmed-article:15867298 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15867298 | pubmed:articleTitle | Bovine glycomacropeptide is anti-inflammatory in rats with hapten-induced colitis. | lld:pubmed |
| pubmed-article:15867298 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, Spain. | lld:pubmed |
| pubmed-article:15867298 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15867298 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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