| pubmed-article:15866048 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15866048 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:15866048 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15866048 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:15866048 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15866048 | pubmed:dateCreated | 2005-5-3 | lld:pubmed |
| pubmed-article:15866048 | pubmed:abstractText | The tripartite motif proteins TRIM-2 and TRIM-3 have been put forward as putative organizers of neuronal outgrowth and structural plasticity. Here, we identified a molluscan orthologue of TRIM-2/3, named L-TRIM, which is up-regulated during in vitro neurite outgrowth of central neurons. In adult animals, L-Trim mRNA is ubiquitously expressed at low levels in the central nervous system and in peripheral tissues. Central nervous system expression of L-Trim mRNA is increased during postnatal brain development and during in vitro and in vivo neuronal regeneration. In vitro double-stranded RNA knock-down of L-Trim mRNA resulted in a >70% inhibition of neurite outgrowth. Together, our data establish a crucial role for L-TRIM in developmental neurite outgrowth and functional neuronal regeneration and indicate that TRIM-2/3 family members may have evolutionary conserved functions in neuronal differentiation. | lld:pubmed |
| pubmed-article:15866048 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15866048 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15866048 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15866048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15866048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15866048 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15866048 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15866048 | pubmed:month | May | lld:pubmed |
| pubmed-article:15866048 | pubmed:issn | 1044-7431 | lld:pubmed |
| pubmed-article:15866048 | pubmed:author | pubmed-author:van MinnenJJ | lld:pubmed |
| pubmed-article:15866048 | pubmed:author | pubmed-author:SpencerG EGE | lld:pubmed |
| pubmed-article:15866048 | pubmed:author | pubmed-author:SmitA BAB | lld:pubmed |
| pubmed-article:15866048 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:15866048 | pubmed:author | pubmed-author:BouwmanJJ | lld:pubmed |
| pubmed-article:15866048 | pubmed:author | pubmed-author:van DiepenM... | lld:pubmed |
| pubmed-article:15866048 | pubmed:author | pubmed-author:GouwenbergYY | lld:pubmed |
| pubmed-article:15866048 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15866048 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:15866048 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15866048 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15866048 | pubmed:pagination | 74-81 | lld:pubmed |
| pubmed-article:15866048 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15866048 | pubmed:meshHeading | pubmed-meshheading:15866048... | lld:pubmed |
| pubmed-article:15866048 | pubmed:meshHeading | pubmed-meshheading:15866048... | lld:pubmed |
| pubmed-article:15866048 | pubmed:meshHeading | pubmed-meshheading:15866048... | lld:pubmed |
| pubmed-article:15866048 | pubmed:meshHeading | pubmed-meshheading:15866048... | lld:pubmed |
| pubmed-article:15866048 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15866048 | pubmed:articleTitle | The molluscan RING-finger protein L-TRIM is essential for neuronal outgrowth. | lld:pubmed |
| pubmed-article:15866048 | pubmed:affiliation | Department of Molecular and Cellular Neurobiology, Faculty of Earth and Life Sciences, Institute of Neuroscience, Vrije Universiteit, De Boelelaan 1085, 1081HV Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:15866048 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15866048 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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