Linked Life Data

1586150

Source:http://linkedlifedata.com/resource/pubmed/id/1586150

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pubmed-article:1586150pubmed:abstractTextRats fed an ethanol-containing diet for 4 weeks showed a 3- to 5-fold increase over isocalorically pair-fed controls with respect to cytosolic NAD(P)H-quinone oxidoreductase (NQOR) (E.C.1.6.99.2) with both menadione and dichlorophenol-indophenol as substrates. Rates of NAD(P)H-dependent p-nitrosophenol (pNSP) reduction catalyzed by rat liver cytosolic fractions were increased 1.5- to 2-fold upon pretreatment of the animal with ethanol. NQOR contributed almost exclusively to the NADPH-dependent C-nitrosoreductase activity in cytosol as judged by the strong inhibition of the reaction by dicoumarol. In contrast, NADH-dependent C-nitrosoreductase activity was inhibited 70-80% by pyrazole and thus may be attributed mainly to alcohol dehydrogenase(s). Highly purified rat liver cytosolic NQOR catalyzed the NADH- and NADPH-dependent reduction of pNSP to p-aminophenol. We therefore suggest that ethanol ingestion enhances the reduction of the C-nitrosoaromatics formed upon cytosolic metabolism of arylamines or nitroarenes by two mechanisms. Increased NADPH-dependent reduction is mediated by the induction of cytosolic NQOR while an NADH-dependent pathway responds to the increased availability of reduced cofactor upon ethanol ingestion and involves mainly the alcohol dehydrogenase-mediated reduction of such compounds.lld:pubmed
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pubmed-article:1586150pubmed:pagination223-9lld:pubmed
pubmed-article:1586150pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:1586150pubmed:year1992lld:pubmed
pubmed-article:1586150pubmed:articleTitleRole of cytosolic NAD(P)H-quinone oxidoreductase and alcohol dehydrogenase in the reduction of p-nitrosophenol following chronic ethanol ingestion.lld:pubmed
pubmed-article:1586150pubmed:affiliationDepartment of Biochemistry, Louisiana State University, Baton Rouge 70803.lld:pubmed
pubmed-article:1586150pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1586150pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed