| pubmed-article:15861127 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15861127 | lifeskim:mentions | umls-concept:C0682460 | lld:lifeskim |
| pubmed-article:15861127 | lifeskim:mentions | umls-concept:C0035736 | lld:lifeskim |
| pubmed-article:15861127 | lifeskim:mentions | umls-concept:C0036220 | lld:lifeskim |
| pubmed-article:15861127 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:15861127 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:15861127 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:15861127 | lifeskim:mentions | umls-concept:C1519595 | lld:lifeskim |
| pubmed-article:15861127 | lifeskim:mentions | umls-concept:C2346714 | lld:lifeskim |
| pubmed-article:15861127 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:15861127 | pubmed:dateCreated | 2005-5-18 | lld:pubmed |
| pubmed-article:15861127 | pubmed:abstractText | The Kaposi's sarcoma-associated herpesvirus produces a 1077 nucleotide noncoding, polyadenylated, exclusively nuclear RNA called PAN that is highly expressed in lytically infected cells. We report that PAN contains a novel post-transcriptional element essential for its abundant accumulation. The element, PAN-ENE (PAN RNA expression and nuclear retention element), increases the efficiency of 3'-end formation in vivo and is sufficient to enhance RNA abundance from an otherwise inefficiently expressed intronless beta-globin construct. The PAN-ENE does not concomitantly increase the production of encoded protein. Rather, it retains the unspliced beta-globin mRNA in the nucleus. Tethering of export factors can override the nuclear retention of the PAN-ENE, supporting a mechanism whereby the PAN-ENE blocks assembly of an export-competent mRNP. The activities of the PAN-ENE are specific to intronless constructs, since inserting the PAN-ENE into a spliced beta-globin construct has no effect on mRNA abundance and does not affect localization. This is the first characterization of a cis-acting element that increases RNA abundance of intronless transcripts but inhibits assembly of an export-competent mRNP. | lld:pubmed |
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| pubmed-article:15861127 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15861127 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15861127 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15861127 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15861127 | pubmed:month | May | lld:pubmed |
| pubmed-article:15861127 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:15861127 | pubmed:author | pubmed-author:SteitzJoan... | lld:pubmed |
| pubmed-article:15861127 | pubmed:author | pubmed-author:ConradNichola... | lld:pubmed |
| pubmed-article:15861127 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15861127 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:15861127 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:15861127 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15861127 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15861127 | pubmed:pagination | 1831-41 | lld:pubmed |
| pubmed-article:15861127 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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