| pubmed-article:15852063 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15852063 | lifeskim:mentions | umls-concept:C0001948 | lld:lifeskim |
| pubmed-article:15852063 | lifeskim:mentions | umls-concept:C0205653 | lld:lifeskim |
| pubmed-article:15852063 | lifeskim:mentions | umls-concept:C0025353 | lld:lifeskim |
| pubmed-article:15852063 | lifeskim:mentions | umls-concept:C0003467 | lld:lifeskim |
| pubmed-article:15852063 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:15852063 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:15852063 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:15852063 | lifeskim:mentions | umls-concept:C0023981 | lld:lifeskim |
| pubmed-article:15852063 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:15852063 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15852063 | pubmed:dateCreated | 2005-8-25 | lld:pubmed |
| pubmed-article:15852063 | pubmed:abstractText | The serotonin transporter gene (5-HTT) encodes a transmembrane protein that plays an important role in regulating serotonergic neurotransmission and related aspects of mood and behaviour. The short allele of a 44 bp insertion/deletion polymorphism (S-allele) within the promoter region of the 5-HTT gene (5-HTTLPR) confers lower transcriptional activity relative to the long allele (L-allele) and may act to modify the risk of serotonin-mediated outcomes such as anxiety and substance use behaviours. The purpose of this study was to determine whether (or not) 5-HTTLPR genotypes moderate known associations between attachment style and adolescent anxiety and alcohol use outcomes. Participants were drawn from an eight-wave study of the mental and behavioural health of a cohort of young Australians followed from 14 to 24 years of age (Victorian Adolescent Health Cohort Study, 1992 - present). No association was observed within low-risk attachment settings. However, within risk settings for heightened anxiety (ie, insecurely attached young people), the odds of persisting ruminative anxiety (worry) decreased with each additional copy of the S-allele (approximately 30% per allele: OR 0.77, 95% CI 0.62-0.97, P=0.029). Within risk settings for binge drinking (ie, securely attached young people), the odds of reporting persisting high-dose alcohol consumption (bingeing) decreased with each additional copy of the S-allele (approximately 35% per allele: OR 0.74, 95% CI 0.64-0.86, P<0.001). Our data suggest that the S-allele is likely to be important in psychosocial development, particularly in those settings that increase risk of anxiety and alcohol use problems. | lld:pubmed |
| pubmed-article:15852063 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15852063 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15852063 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15852063 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15852063 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15852063 | pubmed:issn | 1359-4184 | lld:pubmed |
| pubmed-article:15852063 | pubmed:author | pubmed-author:WilliamsonRR | lld:pubmed |
| pubmed-article:15852063 | pubmed:author | pubmed-author:OlssonC ACA | lld:pubmed |
| pubmed-article:15852063 | pubmed:author | pubmed-author:PattonCC | lld:pubmed |
| pubmed-article:15852063 | pubmed:author | pubmed-author:CollinsVV | lld:pubmed |
| pubmed-article:15852063 | pubmed:author | pubmed-author:Lotfi-MiriMM | lld:pubmed |
| pubmed-article:15852063 | pubmed:author | pubmed-author:ByrnesG BGB | lld:pubmed |
| pubmed-article:15852063 | pubmed:author | pubmed-author:AnneyR J LRJ | lld:pubmed |
| pubmed-article:15852063 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15852063 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:15852063 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15852063 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15852063 | pubmed:pagination | 868-76 | lld:pubmed |
| pubmed-article:15852063 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15852063 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15852063 | pubmed:articleTitle | Association between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use: results from a 10-year longitudinal study of adolescent mental health. | lld:pubmed |
| pubmed-article:15852063 | pubmed:affiliation | Centre for Adolescent Health, Murdoch Childrens Research Institute, Royal Children's Hospital, The University of Melbourne, Victoria, Australia. craig.olsson@rch.org.au | lld:pubmed |
| pubmed-article:15852063 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15852063 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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