| pubmed-article:15851488 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15851488 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:15851488 | lifeskim:mentions | umls-concept:C1955941 | lld:lifeskim |
| pubmed-article:15851488 | lifeskim:mentions | umls-concept:C1414070 | lld:lifeskim |
| pubmed-article:15851488 | lifeskim:mentions | umls-concept:C0178587 | lld:lifeskim |
| pubmed-article:15851488 | lifeskim:mentions | umls-concept:C1749388 | lld:lifeskim |
| pubmed-article:15851488 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:15851488 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15851488 | pubmed:dateCreated | 2005-5-3 | lld:pubmed |
| pubmed-article:15851488 | pubmed:abstractText | Notch signaling regulates multiple cell fate decisions by hematopoietic precursors. To address whether different amounts of Notch ligand influence lineage choices, we cultured murine bone marrow lin(-)Sca-1(+)c-kit+ cells with increasing densities of immobilized Delta1(ext-IgG) consisting of the extracellular domain of Delta1 fused to the Fc domain of human IgG1. We found that relatively lower densities of Delta1(ext-IgG) enhanced the generation of Sca-1(+)c-kit+ cells, Thy1(+)CD25+ early T cell precursors, and B220(+)CD43(-/lo) cells that, when cocultured with OP9 stroma cells, differentiated into CD19+ early B cell precursors. Higher densities of Delta1(ext-IgG) also enhanced the generation of Sca-1(+)c-kit+ precursor cells and promoted the development of Thy1(+)CD25+ cells, but inhibited the development of B220(+)CD43(-/lo) cells. Analyses of further isolated precursor populations suggested that the enhanced generation of T and B cell precursors resulted from the effects on multipotent rather than lymphoid-committed precursors. The results demonstrate the density-dependent effects of Delta1 on fate decisions of hematopoietic precursors at multiple maturational stages and substantiate the previously unrecognized ability of Delta1 to enhance the development of both early B and T precursor cells. | lld:pubmed |
| pubmed-article:15851488 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15851488 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15851488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15851488 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15851488 | pubmed:month | May | lld:pubmed |
| pubmed-article:15851488 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15851488 | pubmed:author | pubmed-author:BernsteinIrwi... | lld:pubmed |
| pubmed-article:15851488 | pubmed:author | pubmed-author:Varnum-Finney... | lld:pubmed |
| pubmed-article:15851488 | pubmed:author | pubmed-author:KatoKeizoK | lld:pubmed |
| pubmed-article:15851488 | pubmed:author | pubmed-author:DelaneyCollee... | lld:pubmed |
| pubmed-article:15851488 | pubmed:author | pubmed-author:DallasMari... | lld:pubmed |
| pubmed-article:15851488 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15851488 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:15851488 | pubmed:volume | 201 | lld:pubmed |
| pubmed-article:15851488 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15851488 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15851488 | pubmed:pagination | 1361-6 | lld:pubmed |
| pubmed-article:15851488 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:meshHeading | pubmed-meshheading:15851488... | lld:pubmed |
| pubmed-article:15851488 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15851488 | pubmed:articleTitle | Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells. | lld:pubmed |
| pubmed-article:15851488 | pubmed:affiliation | Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. | lld:pubmed |
| pubmed-article:15851488 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15851488 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15851488 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15851488 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15851488 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
